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Uroc1 Gene Detail
Summary
  • Symbol
    Uroc1
  • Name
    urocanase domain containing 1
  • Synonyms
    MGC:37818
  • Feature Type
    protein coding gene
  • IDs
    MGI:2385332
    NCBI Gene: 243537
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:90310266-90341533 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 40.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    906 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2385332
 protein coding gene Chr6:90310221-90341533 (+)
129S1/SvImJ ENSMUSG00200041073
 protein coding gene Chr6:87255827-87287169 (+)
A/J ENSMUSG00195034056
 protein coding gene Chr6:86977832-87009282 (+)
AKR/J ENSMUSG00220029408
 protein coding gene Chr6:85882171-85913442 (+)
BALB/cJ ENSMUSG00180015514
 protein coding gene Chr6:87344349-87375620 (+)
C3H/HeJ ENSMUSG00175024027
 protein coding gene Chr6:90057330-90088678 (-)
C57BL/6NJ ENSMUSG00215021143
 protein coding gene Chr6:87345221-87376488 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028643
 protein coding gene Chr6:86360098-86389336 (+)
CAST/EiJ ENSTCUG00005017309
 protein coding gene Chr6:87464037-87495486 (+)
CBA/J ENSMUSG00210043415
 protein coding gene Chr6:87131543-87162883 (+)
DBA/2J ENSMUSG00185039957
 protein coding gene Chr6:87678899-87710247 (+)
FVB/NJ ENSMUSG00205026863
 protein coding gene Chr6:86311976-86343316 (+)
JF1/MsJ ENSUMUG00000042773
 protein coding gene Chr6:86619599-86651158 (+)
LP/J ENSMUSG00230049332
 protein coding gene Chr6:88813593-88844932 (+)
NOD/ShiLtJ ENSMUSG00190026871
 protein coding gene Chr6:86750707-86782045 (+)
NZO/HlLtJ ENSMUSG00225016629
 protein coding gene Chr6:90819991-90851254 (+)
PWK/PhJ ENSLUMG00010028537
 protein coding gene Chr6:86044289-86075553 (+)
SPRET/EiJ ENSMSPG00010030862
 protein coding gene Chr6:88306610-88338084 (+)
WSB/EiJ ENSIUOG00005030413
 protein coding gene Chr6:87747519-87778965 (+)



Homology
more
  • Human Ortholog
    UROC1, urocanate hydratase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UROC1, urocanate hydratase 1
  • Synonyms
    HMFN0320, UROCD
  • Links
    NCBI Gene ID: 131669
    UniProt: Q96N76

  • Chr Location
    3q21.3; chr3:126481165-126517777 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human UROC1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    94
  • cDNA Data
    17
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034456 Ensembl Gene Model | MGI Sequence Detail 31268 C57BL/6J ±  kb
    transcript ENSMUST00000164761 Ensembl | MGI Sequence Detail 3462 Not Applicable  
    polypeptide ENSMUSP00000127114 Ensembl | MGI Sequence Detail 710 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 17

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2141387
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 2
      Gene Ontology 6
      Phenotypes 19
    • Earliest
      J:21726 Champion KM, et al., Identification of a heritable deficiency of the folate-dependent enzyme 10-formyltetrahydrofolate dehydrogenase in mice. Proc Natl Acad Sci U S A. 1994 Nov 22;91(24):11338-42
    • Latest
      J:386463 Rias E, et al., Protocol for isolation of total RNA from mouse whole cochlea using organic solvents. STAR Protoc. 2026 Mar 20;7(1):104376
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory