Tesk2 MGI Mouse Gene Detail - MGI:2385204

Symbol

Tesk2
Name

testis-specific kinase 2

Feature Type

protein coding gene
IDs

MGI:2385204
NCBI Gene: 230661
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr4:116578107-116661450 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 53.30 cM
Mapping Data

2 experiments

SNPs within 2kb

2266 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2385204	protein coding gene	Chr4:116578107-116663153 (+)
129S1/SvImJ	ENSMUSG00200048875	protein coding gene	Chr4:110474421-110559435 (+)
A/J	ENSMUSG00195046923	protein coding gene	Chr4:111739444-111824659 (+)
AKR/J	ENSMUSG00220010959	protein coding gene	Chr4:111087670-111173122 (+)
BALB/cJ	ENSMUSG00180041176	protein coding gene	Chr4:109812339-109898193 (+)
C3H/HeJ	ENSMUSG00175040390	protein coding gene	Chr4:110826750-110912581 (+)
C57BL/6NJ	ENSMUSG00215034947	protein coding gene	Chr4:111902356-111987376 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026341	protein coding gene	Chr4:107162644-107253571 (+)
CAST/EiJ	ENSTCUG00005019995	protein coding gene	Chr4:110596359-110683456 (+)
CBA/J	ENSMUSG00210053009	protein coding gene	Chr4:110440420-110526259 (+)
DBA/2J	ENSMUSG00185047452	protein coding gene	Chr4:111965090-112050294 (+)
FVB/NJ	ENSMUSG00205039967	protein coding gene	Chr4:109909801-109995646 (+)
JF1/MsJ	ENSUMUG00000024128	protein coding gene	Chr4:111865944-111952358 (+)
LP/J	ENSMUSG00230045764	protein coding gene	Chr4:115291692-115376709 (+)
NOD/ShiLtJ	ENSMUSG00190046439	protein coding gene	Chr4:109808578-109894410 (+)
NZO/HlLtJ	ENSMUSG00225010788	protein coding gene	Chr4:120779653-120865102 (+)
PWK/PhJ	ENSLUMG00010045567	protein coding gene	Chr4:109265227-109351456 (+)
SPRET/EiJ	ENSMSPG00010028271	protein coding gene	Chr4:111370357-111456357 (+)
WSB/EiJ	ENSIUOG00005038318	protein coding gene	Chr4:110127424-110212429 (+)

Human Ortholog

TESK2, testis associated actin remodelling kinase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TESK2, testis associated actin remodelling kinase 2
Links

HGNC:11732

NCBI Gene ID: 10420

UniProt: Q96S53
Chr Location

1p34.1; chr1:45343877-45491203 (-) GRCh38

MGI Vertebrate Homology

Tesk2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: TESK2
Gene Tree

Tesk2

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

78
Chemically induced (other)

2
Endonuclease-mediated

5
Gene trapped

67
Radiation induced

1
Targeted

3
Genomic Mutations

4 involving Tesk2
Incidental Mutations

APF
Find Mice (IMSR)

212 strains or lines available

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All GO Annotations

29
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

713
Tissues

99
cDNA Data

24
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tesk2

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All Sequences

50
RefSeq

6
UniProt

6
CCDS

CCDS18516.1

Ensembl

ENSMUSG00000033985 (Evidence)
NCBI Gene

230661

			Length	Strain/Species	Flank
genomic	230661	NCBI Gene Model \| MGI Sequence Detail	83344	C57BL/6J	± kb
transcript	NM_146151	RefSeq \| MGI Sequence Detail	3032	C57BL/6
polypeptide	Q8VCT9	UniProt \| EBI \| MGI Sequence Detail	570	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000016242 dual specificity testis-specific protein kinase 2

(term hierarchy)
EC

2.7.12.1
InterPro Domains

IPR050940 Actin-regulating Serine/Threonine Kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR008266 Tyrosine-protein kinase, active site

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All nucleic 26

cDNA 24

Primer pair 2

Microarray probesets 2

Summaries

All 51

Developmental Gene Expression 3

Gene Ontology 9

Phenotypes 18
Earliest

J:62058 Zuercher G, et al., A novel member of the testis specific serine kinase family, tssk-3, expressed in the leydig cells of sexually mature mice. Mech Dev. 2000 May;93(1-2):175-7
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Tesk2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr38581	Chr4:116578117-116578201 (+)	52 bp
Tssr38582	Chr4:116578264-116578275 (+)	163 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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