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Cplx3 Gene Detail
Summary
  • Symbol
    Cplx3
  • Name
    complexin 3
  • Synonyms
    CpxIII, Lman1l, MGC:21420, MGC:38804
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384571
    NCBI Gene: 235415
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:57507275-57513564 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 31.11 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    206 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384571
 protein coding gene Chr9:57507275-57513564 (-)
129S1/SvImJ ENSMUSG00200032384
 protein coding gene Chr9:54632831-54639138 (-)
A/J ENSMUSG00195038333
 protein coding gene Chr9:54332999-54339303 (-)
AKR/J ENSMUSG00220027978
 protein coding gene Chr9:54473840-54480152 (-)
BALB/cJ ENSMUSG00180016288
 protein coding gene Chr9:54446600-54452885 (-)
C3H/HeJ ENSMUSG00175021645
 protein coding gene Chr9:54459800-54466105 (-)
C57BL/6NJ ENSMUSG00215022600
 protein coding gene Chr9:54439958-54446250 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032275
 protein coding gene Chr9:54289511-54295831 (-)
CAST/EiJ ENSTCUG00005018618
 protein coding gene Chr9:54363543-54369858 (-)
CBA/J ENSMUSG00210036901
 protein coding gene Chr9:54568048-54574375 (-)
DBA/2J ENSMUSG00185039743
 protein coding gene Chr9:54590344-54596654 (-)
FVB/NJ ENSMUSG00205027881
 protein coding gene Chr9:54897126-54903432 (-)
JF1/MsJ ENSUMUG00000025204
 protein coding gene Chr9:54606771-54613128 (-)
LP/J ENSMUSG00230033209
 protein coding gene Chr9:54832612-54838917 (-)
NOD/ShiLtJ ENSMUSG00190042059
 protein coding gene Chr9:54658354-54664655 (-)
NZO/HlLtJ ENSMUSG00225026899
 protein coding gene Chr9:54871375-54877674 (-)
PWK/PhJ ENSLUMG00010038001
 protein coding gene Chr9:54562090-54568395 (-)
SPRET/EiJ ENSMSPG00010023782
 protein coding gene Chr9:55608882-55618781 (-)
WSB/EiJ ENSIUOG00005034329
 protein coding gene Chr9:54072194-54078499 (-)



Homology
more
  • Human Ortholog
    CPLX3, complexin 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CPLX3, complexin 3
  • Synonyms
    CPX-III, CPXIII, Nbla11589
  • Links
    NCBI Gene ID: 594855
    UniProt: Q8WVH0

  • Chr Location
    15q24.1; chr15:74826627-74831802 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    16 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele are fertile, viable and exhibit normal synaptic transmission.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    619
  • Tissues
    7
  • cDNA Data
    18
  • Literature Summary
    9
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 235415 NCBI Gene Model | MGI Sequence Detail 6290 C57BL/6J ±  kb
transcript NM_146223 RefSeq | MGI Sequence Detail 2859 C57BL/6  
polypeptide Q8R1B5 UniProt | EBI | MGI Sequence Detail 158 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    cDNA 18
    Primer pair 2
    Antibodies 1

    Microarray probesets 3
References
more
  • Summaries
    All 60
    Developmental Gene Expression 9
    Gene Ontology 6
    Phenotypes 21
  • Earliest
    J:99464 Reim K, et al., Structurally and functionally unique complexins at retinal ribbon synapses. J Cell Biol. 2005 May 23;169(4):669-80
  • Latest
    J:374677 Liwang JK, et al., epDevAtlas: mapping GABAergic cells and microglia in the early postnatal mouse brain. Nat Commun. 2025 Oct 29;16(1):9538
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory