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Myrip Gene Detail
Summary
  • Symbol
    Myrip
  • Name
    myosin VIIA and Rab interacting protein
  • Synonyms
    A230081N12Rik, Slac2-c
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384407
    NCBI Gene: 245049
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:120132996-120305167 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 71.50 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    5978 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2384407
 protein coding gene Chr9:120130579-120305167 (+)
129S1/SvImJ ENSMUSG00200027634
 protein coding gene Chr9:117252993-117426392 (+)
A/J ENSMUSG00195028058
 protein coding gene Chr9:116427938-116601428 (+)
AKR/J ENSMUSG00220019407
 protein coding gene Chr9:116883370-117062353 (+)
BALB/cJ ENSMUSG00180027793
 protein coding gene Chr9:116965225-117138706 (+)
C3H/HeJ ENSMUSG00175017609
 protein coding gene Chr9:117208518-117381980 (+)
C57BL/6NJ ENSMUSG00215023358
 protein coding gene Chr9:117084285-117257681 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032816
 protein coding gene Chr9:115712299-115881736 (+)
CAST/EiJ ENSTCUG00005015321
 protein coding gene Chr9:116834354-117007095 (+)
CBA/J ENSMUSG00210032158
 protein coding gene Chr9:116922189-117101163 (+)
DBA/2J ENSMUSG00185016539
 protein coding gene Chr9:117256429-117435410 (+)
FVB/NJ ENSMUSG00205018598
 protein coding gene Chr9:117096716-117270178 (+)
JF1/MsJ ENSUMUG00000030934
 protein coding gene Chr9:117117581-117290206 (+)
LP/J ENSMUSG00230031422
 protein coding gene Chr9:117381316-117554700 (+)
NOD/ShiLtJ ENSMUSG00190014375
 protein coding gene Chr9:116862686-117036060 (+)
NZO/HlLtJ ENSMUSG00225023619
 protein coding gene Chr9:117645867-117819248 (+)
PWK/PhJ ENSLUMG00010035098
 protein coding gene Chr9:117004698-117178382 (+)
SPRET/EiJ ENSMSPG00010023206
 protein coding gene Chr9:118704482-118877252 (+)
WSB/EiJ ENSIUOG00005018702
 protein coding gene Chr9:116311041-116484288 (+)



Homology
more
  • Human Ortholog
    MYRIP, myosin VIIA and Rab interacting protein
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYRIP, myosin VIIA and Rab interacting protein
  • Synonyms
    SLAC2-C, SLAC2C
  • Links
    NCBI Gene ID: 25924
    UniProt: Q8NFW9

  • Chr Location
    3p22.1; chr3:39808914-40260321 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit glucose intolerance, decreased insulin secretion, and abnormal insulin granule localization in beta-cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    627
  • Tissues
    21
  • cDNA Data
    14
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 245049 NCBI Gene Model | MGI Sequence Detail 172172 C57BL/6J ±  kb
    transcript NM_144557 RefSeq | MGI Sequence Detail 4762 C57BL/6  
    polypeptide Q8K3I4 UniProt | EBI | MGI Sequence Detail 856 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 2
      cDNA 14
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2444163
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 2
      Gene Ontology 10
      Phenotypes 9
    • Earliest
      J:76844 El-Amraoui A, et al., MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomes. EMBO Rep. 2002 May;3(5):463-70
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory