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Acsf3 Gene Detail
Summary
  • Symbol
    Acsf3
  • Name
    acyl-CoA synthetase family member 3
  • Synonyms
    MGC:37904
  • Feature Type
    protein coding gene
  • IDs
    MGI:2182591
    NCBI Gene: 257633
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:123502225-123544619 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 71.97 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1101 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2182591
 protein coding gene Chr8:123502209-123544626 (+)
129S1/SvImJ ENSMUSG00200042305
 protein coding gene Chr8:117832664-117879408 (+)
A/J ENSMUSG00195025854
 protein coding gene Chr8:118122958-118176904 (+)
AKR/J ENSMUSG00220036557
 protein coding gene Chr8:118314098-118368035 (+)
BALB/cJ ENSMUSG00180021756
 protein coding gene Chr8:118168989-118222925 (+)
C3H/HeJ ENSMUSG00175027896
 protein coding gene Chr8:118225836-118279770 (+)
C57BL/6NJ ENSMUSG00215019859
 protein coding gene Chr8:117808204-117853890 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031672
 protein coding gene Chr8:113939641-113979768 (+)
CAST/EiJ ENSTCUG00005030927
 protein coding gene Chr8:117554743-117601488 (+)
CBA/J ENSMUSG00210035488
 protein coding gene Chr8:118160664-118206345 (+)
DBA/2J ENSMUSG00185033874
 protein coding gene Chr8:124265595-124311279 (+)
FVB/NJ ENSMUSG00205026406
 protein coding gene Chr8:117126849-117172533 (+)
JF1/MsJ ENSUMUG00000014316
 protein coding gene Chr8:126563874-126609382 (+)
LP/J ENSMUSG00230030215
 protein coding gene Chr8:127884104-127930843 (+)
NOD/ShiLtJ ENSMUSG00190017606
 protein coding gene Chr8:118261157-118306825 (+)
NZO/HlLtJ ENSMUSG00225041981
 protein coding gene Chr8:131266081-131311763 (+)
PWK/PhJ ENSLUMG00010035512
 protein coding gene Chr8:117968371-118013924 (+)
SPRET/EiJ ENSMSPG00010035234
 protein coding gene Chr8:120162626-120203306 (+)
WSB/EiJ ENSIUOG00005026588
 protein coding gene Chr8:118953301-118999048 (+)



Homology
more
  • Human Ortholog
    ACSF3, acyl-CoA synthetase family member 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACSF3, acyl-CoA synthetase family member 3
  • Links
    NCBI Gene ID: 197322
    UniProt: Q4G176

  • Chr Location
    16q24.3; chr16:89088375-89164121 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ACSF3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    41
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015016 Ensembl Gene Model | MGI Sequence Detail 42395 C57BL/6J ±  kb
    transcript ENSMUST00000015160 Ensembl | MGI Sequence Detail 2206 Not Applicable  
    polypeptide ENSMUSP00000015160 Ensembl | MGI Sequence Detail 583 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 41

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2144599
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 1
      Gene Ontology 9
      Phenotypes 9
    • Earliest
      J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
    • Latest
      J:389143 Zhang Y, et al., An ancient regulatory variant of ACSF3 influences the coevolution of increased human height and basal metabolic rate via metabolic homeostasis. Cell Genom. 2025 Jun 11;5(6):100855
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory