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Irak4 Gene Detail
Summary
  • Symbol
    Irak4
  • Name
    interleukin-1 receptor-associated kinase 4
  • Synonyms
    8430405M07Rik, 9330209D03Rik, IRAK-4, NY-REN-64
  • Feature Type
    protein coding gene
  • IDs
    MGI:2182474
    NCBI Gene: 266632
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:94441495-94466198 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 48.55 cM, cytoband F1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    914 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2182474
 protein coding gene Chr15:94441495-94479696 (+)
129S1/SvImJ ENSMUSG00200034762
 protein coding gene Chr15:91567394-91611913 (+)
A/J ENSMUSG00195039142
 protein coding gene Chr15:91475359-91519880 (+)
AKR/J ENSMUSG00220046013
 protein coding gene Chr15:91525967-91570490 (+)
BALB/cJ ENSMUSG00180044544
 protein coding gene Chr15:91370449-91408628 (+)
C3H/HeJ ENSMUSG00175032521
 protein coding gene Chr15:91661750-91706266 (+)
C57BL/6NJ ENSMUSG00215048930
 protein coding gene Chr15:91474736-91512918 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020196
 protein coding gene Chr15:88303295-88328755 (+)
CAST/EiJ ENSTCUG00005029462
 protein coding gene Chr15:90958353-90998526 (+)
CBA/J ENSMUSG00210026139
 protein coding gene Chr15:91442999-91487525 (+)
DBA/2J ENSMUSG00185033616
 protein coding gene Chr15:91491147-91535664 (+)
FVB/NJ ENSMUSG00205033495
 protein coding gene Chr15:91184765-91229286 (+)
JF1/MsJ ENSUMUG00000021149
 protein coding gene Chr15:90979441-91018778 (+)
LP/J ENSMUSG00230031938
 protein coding gene Chr15:94805326-94849840 (+)
NOD/ShiLtJ ENSMUSG00190040556
 protein coding gene Chr15:91497984-91542499 (+)
NZO/HlLtJ ENSMUSG00225042413
 protein coding gene Chr15:95108636-95153147 (+)
PWK/PhJ ENSLUMG00010033383
 protein coding gene Chr15:91143147-91187665 (+)
SPRET/EiJ ENSMSPG00010038265
 protein coding gene Chr15:92950322-92988020 (+)
WSB/EiJ ENSIUOG00005011013
 protein coding gene Chr15:91561108-91599138 (+)



Homology
more
  • Human Ortholog
    IRAK4, interleukin 1 receptor associated kinase 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IRAK4, interleukin 1 receptor associated kinase 4
  • Synonyms
    IMD67, IPD1, IRAK-4, NY-REN-64, REN64
  • Links
    NCBI Gene ID: 51135
    UniProt: Q9NWZ3

  • Chr Location
    12q12; chr12:43758944-43798307 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with human IRAK4 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 6 alleles in 6 genetic backgrounds
    8 phenotypes from multigenic genotypes
    68 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit defects of the innate immune system and show increased susceptibility to bacterial infection.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    54
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    669
  • Tissues
    49
  • cDNA Data
    17
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 266632 NCBI Gene Model | MGI Sequence Detail 24704 C57BL/6J ±  kb
    transcript NM_029926 RefSeq | MGI Sequence Detail 2825 C57BL/6  
    polypeptide Q8R4K2 UniProt | EBI | MGI Sequence Detail 459 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 17
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1918735, MGI:1924812
    References
    more
    • Summaries
      All 145
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 16
      Phenotypes 68
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory