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Neto1 Gene Detail
Summary
  • Symbol
    Neto1
  • Name
    neuropilin (NRP) and tolloid (TLL)-like 1
  • Synonyms
    C130005O10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2180216
    NCBI Gene: 246317
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:86413077-86524843 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 58.47 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3503 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2180216
 protein coding gene Chr18:86411110-86524843 (+)
129S1/SvImJ ENSMUSG00200015088
 protein coding gene Chr18:83693882-83805739 (+)
A/J ENSMUSG00195001296
 protein coding gene Chr18:83715926-83828045 (+)
AKR/J ENSMUSG00220016513
 protein coding gene Chr18:83623475-83735596 (+)
BALB/cJ ENSMUSG00180002447
 protein coding gene Chr18:84267973-84380079 (+)
C3H/HeJ ENSMUSG00175018625
 protein coding gene Chr18:83820349-83932467 (+)
C57BL/6NJ ENSMUSG00215004226
 protein coding gene Chr18:83213555-83325337 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022456
 protein coding gene Chr18:82290524-82399608 (+)
CAST/EiJ ENSTCUG00005005394
 protein coding gene Chr18:82747346-82859487 (+)
CBA/J ENSMUSG00210017875
 protein coding gene Chr18:83761037-83873142 (+)
DBA/2J ENSMUSG00185004165
 protein coding gene Chr18:83663626-83775731 (+)
FVB/NJ ENSMUSG00205013610
 protein coding gene Chr18:83062912-83175046 (+)
JF1/MsJ ENSUMUG00000015241
 protein coding gene Chr18:83516944-83629357 (+)
LP/J ENSMUSG00230017395
 protein coding gene Chr18:85757090-85868941 (+)
NOD/ShiLtJ ENSMUSG00190003324
 protein coding gene Chr18:83478689-83590784 (+)
NZO/HlLtJ ENSMUSG00225023467
 protein coding gene Chr18:85661530-85773292 (+)
PWK/PhJ ENSLUMG00010004034
 protein coding gene Chr18:83897081-84009348 (+)
SPRET/EiJ ENSMSPG00010001273
 protein coding gene Chr18:84384627-84494931 (+)
WSB/EiJ ENSIUOG00005016045
 protein coding gene Chr18:83139407-83251299 (+)



Homology
more
  • Human Ortholog
    NETO1, neuropilin and tolloid like 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NETO1, neuropilin and tolloid like 1
  • Synonyms
    BCTL1, BTCL1
  • Links
    NCBI Gene ID: 81832
    UniProt: Q8TDF5

  • Chr Location
    18q22.3; chr18:72742314-72868146 (-)  GRCh38
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    236 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit depressed long term potentiation, reduced NMDAR excitatory postsynaptic potentiation, and decreased spartial learning and working memory.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    43
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    699
  • Tissues
    68
  • cDNA Data
    8
  • Literature Summary
    11
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050321 Ensembl Gene Model | MGI Sequence Detail 111767 C57BL/6J ±  kb
transcript ENSMUST00000058829 Ensembl | MGI Sequence Detail 8352 Not Applicable  
polypeptide ENSMUSP00000057340 Ensembl | MGI Sequence Detail 533 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000011143 neuropilin and tolloid-like protein 1
    (term hierarchy)
  • InterPro Domains
    IPR000859 CUB domain
    IPR036055 LDL receptor-like superfamily
    IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
    IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
    IPR035914 Spermadhesin, CUB domain superfamily
  • GlyGen
    Q8R4I7 3 sites, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 12
    cDNA 8
    Primer pair 2
    Other 2

    Microarray probesets 5
Other
Accession IDs
less
MGI:2147275, MGI:2443543
References
more
  • Summaries
    All 272
    Developmental Gene Expression 11
    Diseases 2
    Gene Ontology 10
    Phenotypes 236
  • Earliest
    J:76401 Stohr H, et al., A novel gene encoding a putative transmembrane protein with two extracellular CUB domains and a low-density lipoprotein class A module: isolation of alternatively spliced isoforms in retina and brain. Gene. 2002 Mar 20;286(2):223-31
  • Latest
    J:389086 Zheng B, et al., Cap 2'-O-methyltransferase CMTR2 regulates male meiosis independent of its methyltransferase activity. Nucleic Acids Res. 2026 Jul 3;54(13)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory