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Mvd Gene Detail
Summary
  • Symbol
    Mvd
  • Name
    mevalonate (diphospho) decarboxylase
  • Feature Type
    protein coding gene
  • IDs
    MGI:2179327
    NCBI Gene: 192156
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:123160340-123170161 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 71.05 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    367 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2179327
 protein coding gene Chr8:123160335-123170161 (-)
129S1/SvImJ ENSMUSG00200042015
 protein coding gene Chr8:117491618-117501437 (-)
A/J ENSMUSG00195023922
 protein coding gene Chr8:117781866-117791687 (-)
AKR/J ENSMUSG00220037555
 protein coding gene Chr8:117973038-117982859 (-)
BALB/cJ ENSMUSG00180027720
 protein coding gene Chr8:117827906-117837728 (-)
C3H/HeJ ENSMUSG00175030666
 protein coding gene Chr8:117884783-117894604 (-)
C57BL/6NJ ENSMUSG00215025595
 protein coding gene Chr8:117466304-117476125 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031661
 protein coding gene Chr8:113593076-113602815 (-)
CAST/EiJ ENSTCUG00005033070
 protein coding gene Chr8:117213023-117222763 (-)
CBA/J ENSMUSG00210030230
 protein coding gene Chr8:117818775-117828596 (-)
DBA/2J ENSMUSG00185031618
 protein coding gene Chr8:123923700-123933521 (-)
FVB/NJ ENSMUSG00205029263
 protein coding gene Chr8:116785001-116794820 (-)
JF1/MsJ ENSUMUG00000011908
 protein coding gene Chr8:126224145-126234138 (-)
LP/J ENSMUSG00230027005
 protein coding gene Chr8:127543067-127552886 (-)
NOD/ShiLtJ ENSMUSG00190016961
 protein coding gene Chr8:117919331-117929150 (-)
NZO/HlLtJ ENSMUSG00225041771
 protein coding gene Chr8:130924177-130933998 (-)
PWK/PhJ ENSLUMG00010033195
 protein coding gene Chr8:117629193-117638999 (-)
SPRET/EiJ ENSMSPG00010033667
 protein coding gene Chr8:119820722-119830660 (-)
WSB/EiJ ENSIUOG00005028420
 protein coding gene Chr8:118613669-118623492 (-)



Homology
more
  • Human Ortholog
    MVD, mevalonate diphosphate decarboxylase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MVD, mevalonate diphosphate decarboxylase
  • Synonyms
    FP17780, MDDase, MPD, POROK7
  • Links
    NCBI Gene ID: 4597
    UniProt: P53602

  • Chr Location
    16q24.2; chr16:88651934-88663161 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MVD associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    43
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    60
  • Literature Summary
    1
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000006517 Ensembl Gene Model | MGI Sequence Detail 9822 C57BL/6J ±  kb
transcript ENSMUST00000006692 Ensembl | MGI Sequence Detail 1756 Not Applicable  
polypeptide ENSMUSP00000006692 Ensembl | MGI Sequence Detail 401 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000010785 diphosphomevalonate decarboxylase
    (term hierarchy)
  • PDB
    3F0N
  • EC
    4.1.1.33
  • InterPro Domains
    IPR029765 Diphosphomevalonate decarboxylase
    IPR053859 Diphosphomevalonate decarboxylase-like N-terminal domain
    IPR005935 Diphosphomevalonate/phosphomevalonate decarboxylase
    IPR036554 GHMP kinase, C-terminal domain superfamily
    IPR041431 Mvd1, C-terminal
    IPR020568 Ribosomal protein uS5 domain 2-type superfamily
    IPR014721 Small ribosomal subunit protein uS5 domain 2-type fold, subgroup
Molecular
Reagents
less
  • All nucleic 61
    cDNA 60
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2142855
References
more
  • Summaries
    All 55
    Developmental Gene Expression 1
    Gene Ontology 17
    Phenotypes 12
  • Earliest
    J:371708 Bruenger E, et al., Determination of isopentenyl diphosphate and farnesyl diphosphate in tissue samples with a comment on secondary regulation of polyisoprenoid biosynthesis. Anal Biochem. 1988 Sep;173(2):321-7
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory