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Rtn4ip1 Gene Detail
Summary
  • Symbol
    Rtn4ip1
  • Name
    reticulon 4 interacting protein 1
  • Synonyms
    D10Ertd690e, NIMP
  • Feature Type
    protein coding gene
  • IDs
    MGI:2178759
    NCBI Gene: 170728
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:43777772-43823860 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 23.12 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1367 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2178759
 protein coding gene Chr10:43777772-43833197 (+)
129S1/SvImJ ENSMUSG00200006520
 protein coding gene Chr10:40672321-40718370 (+)
A/J ENSMUSG00195002821
 protein coding gene Chr10:40945382-40991438 (+)
AKR/J ENSMUSG00220005539
 protein coding gene Chr10:40631215-40677273 (+)
BALB/cJ ENSMUSG00180011381
 protein coding gene Chr10:41034665-41080721 (+)
C3H/HeJ ENSMUSG00175009981
 protein coding gene Chr10:40822086-40868141 (+)
C57BL/6NJ ENSMUSG00215002200
 protein coding gene Chr10:40572124-40618182 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015292
 protein coding gene Chr10:39434124-39483324 (+)
CAST/EiJ ENSTCUG00005008228
 protein coding gene Chr10:41018694-41079253 (+)
CBA/J ENSMUSG00210008157
 protein coding gene Chr10:40717766-40763821 (+)
DBA/2J ENSMUSG00185003189
 protein coding gene Chr10:40869283-40915338 (+)
FVB/NJ ENSMUSG00205004285
 protein coding gene Chr10:40784680-40830737 (+)
JF1/MsJ ENSUMUG00000024123
 protein coding gene Chr10:40668223-40715197 (+)
LP/J ENSMUSG00230005351
 protein coding gene Chr10:42670352-42716400 (+)
NOD/ShiLtJ ENSMUSG00190005391
 protein coding gene Chr10:40997518-41043574 (+)
NZO/HlLtJ ENSMUSG00225016962
 protein coding gene Chr10:46959225-47005282 (+)
PWK/PhJ ENSLUMG00010004363
 protein coding gene Chr10:40775113-40835238 (+)
SPRET/EiJ ENSMSPG00010012751
 protein coding gene Chr10:41821264-41867076 (+)
WSB/EiJ ENSIUOG00005014650
 protein coding gene Chr10:40550680-40596731 (+)



Homology
more
  • Human Ortholog
    RTN4IP1, reticulon 4 interacting protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RTN4IP1, reticulon 4 interacting protein 1
  • Synonyms
    NIMP, OPA10, Yim1
  • Links
    NCBI Gene ID: 84816
    UniProt: Q8WWV3

  • Chr Location
    6q21; chr6:106570771-106630491 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RTN4IP1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    3
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Rtn4ip1
  • Incidental Mutations
    Mutagenetix , APF
  • Find Mice (IMSR)
    23 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    647
  • Tissues
    42
  • cDNA Data
    33
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 170728 NCBI Gene Model | MGI Sequence Detail 46089 C57BL/6J ±  kb
transcript NM_130892 RefSeq | MGI Sequence Detail 2982 C57BL/6  
polypeptide Q924D0 UniProt | EBI | MGI Sequence Detail 396 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000014349 reticulon-4-interacting protein 1
    (term hierarchy)
  • EC
    1.6.5.-
  • InterPro Domains
    IPR013154 Alcohol dehydrogenase-like, N-terminal
    IPR020843 Enoylreductase domain
    IPR011032 GroES-like superfamily
    IPR036291 NAD(P)-binding domain superfamily
    IPR037397 NAD(P)H oxidoreductase RTN4IP1, mitochondrial
    IPR002364 Quinone oxidoreductase/zeta-crystallin, conserved site
    IPR050700 YIM1 and Zinc-containing Alcohol Dehydrogenase Families
  • GlyGen
    Q924D0 2 sites, 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 34
    cDNA 33
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:1277154
References
more
  • Summaries
    All 52
    Developmental Gene Expression 3
    Gene Ontology 11
    Phenotypes 17
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:345912 Park I, et al., Mitochondrial matrix RTN4IP1/OPA10 is an oxidoreductase for coenzyme Q synthesis. Nat Chem Biol. 2024 Feb;20(2):221-233
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory