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Tchh Gene Detail
Summary
  • Symbol
    Tchh
  • Name
    trichohyalin
  • Synonyms
    AHF, Thh
  • Feature Type
    protein coding gene
  • IDs
    MGI:2177944
    NCBI Gene: 99681
  • Alliance
  • Transcription Start Sites
    69 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:93349637-93356384 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 3, 40.51 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    186 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2177944
protein coding gene Chr3:93348071-93356384 (+)
129S1/SvImJ ENSMUSG00200038713
protein coding gene Chr3:90154616-90161363 (+)
A/J ENSMUSG00195050162
protein coding gene Chr3:90162441-90169188 (+)
AKR/J ENSMUSG00220046512
protein coding gene Chr3:89369887-89376634 (+)
BALB/cJ ENSMUSG00180045415
protein coding gene Chr3:90311647-90318274 (+)
C3H/HeJ ENSMUSG00175039528
protein coding gene Chr3:90105485-90112232 (+)
C57BL/6NJ ENSMUSG00215049531
protein coding gene Chr3:90693419-90700166 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025301
protein coding gene Chr3:87617295-87625535 (+)
CAST/EiJ ENSTCUG00005046863
protein coding gene Chr3:90466910-90473588 (+)
CBA/J ENSMUSG00210046563
protein coding gene Chr3:90212314-90219061 (+)
DBA/2J ENSMUSG00185052585
protein coding gene Chr3:90418274-90425022 (+)
FVB/NJ ENSMUSG00205044717
protein coding gene Chr3:89195432-89202179 (+)
JF1/MsJ ENSUMUG00000047354
protein coding gene Chr3:89987250-89993805 (+)
LP/J ENSMUSG00230041226
protein coding gene Chr3:92451550-92458297 (+)
NOD/ShiLtJ ENSMUSG00190030416
protein coding gene Chr3:90572896-90579643 (+)
NZO/HlLtJ ENSMUSG00225008043
protein coding gene Chr3:95276213-95282840 (+)
PWK/PhJ ENSLUMG00010041544
protein coding gene Chr3:90017760-90024333 (+)
SPRET/EiJ ENSMSPG00010049423
protein coding gene Chr3:90511180-90517812 (+)
WSB/EiJ ENSIUOG00005046307
protein coding gene Chr3:90723241-90729952 (+)



Homology
more
  • Human Ortholog
    TCHH, trichohyalin
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TCHH, trichohyalin
  • Synonyms
    THH, THL, TRHY, UHS3
  • Links
    NCBI Gene ID: 7062
    UniProt: Q07283

  • Chr Location
    1q21.3; chr1:152106317-152115444 (-)  GRCh38

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000052415 Ensembl Gene Model | MGI Sequence Detail 6748 C57BL/6J ±  kb
transcript ENSMUST00000064257 Ensembl | MGI Sequence Detail 5823 Not Applicable  
polypeptide ENSMUSP00000069525 Ensembl | MGI Sequence Detail 1599 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    cDNA 20
    Primer pair 1
    Antibodies 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2139762
References
more
  • Summaries
    All 63
    Developmental Gene Expression 30
    Diseases 1
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:74930 Steinert PM, et al., Biochemical evidence that small proline-rich proteins and trichohyalin function in epithelia by modulation of the biomechanical properties of their cornified cell envelopes. J Biol Chem. 1998 May 8;273(19):11758-69
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
09/08/2026
MGI 6.24
The Jackson Laboratory