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Ms4a3 Gene Detail
Summary
  • Symbol
    Ms4a3
  • Name
    membrane-spanning 4-domains, subfamily A, member 3
  • Synonyms
    haematopoietic cell-specific transmembrane-4, HTm4
  • Feature Type
    protein coding gene
  • IDs
    MGI:2158468
    NCBI Gene: 170813
  • Member of
    Ms4ac cluster
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:11606863-11618215 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 8.47 cM, cytoband B
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    483 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2158468
 protein coding gene Chr19:11606860-11618215 (-)
129S1/SvImJ ENSMUSG00200046242
 protein coding gene Chr19:8294479-8305817 (-)
A/J ENSMUSG00195045268
 protein coding gene Chr19:8492358-8503690 (-)
AKR/J ENSMUSG00220042686
 protein coding gene Chr19:8402836-8414174 (-)
BALB/cJ ENSMUSG00180044056
 protein coding gene Chr19:8856933-8868263 (-)
C3H/HeJ ENSMUSG00175009089
 protein coding gene Chr19:8133410-8144748 (-)
C57BL/6NJ ENSMUSG00215044071
 protein coding gene Chr19:8205017-8216355 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022726
 protein coding gene Chr19:8865405-8876406 (-)
CAST/EiJ ENSTCUG00005025828
 protein coding gene Chr19:7983021-7994394 (-)
CBA/J ENSMUSG00210033173
 protein coding gene Chr19:8331928-8343264 (-)
DBA/2J ENSMUSG00185046329
 protein coding gene Chr19:8741934-8753276 (-)
FVB/NJ ENSMUSG00205044476
 protein coding gene Chr19:8199789-8211161 (-)
JF1/MsJ ENSUMUG00000054895
 protein coding gene Chr19:8852928-8864902 (-)
LP/J ENSMUSG00230053512
 protein coding gene Chr19:9662280-9673618 (-)
NOD/ShiLtJ ENSMUSG00190050987
 protein coding gene Chr19:7955001-7966331 (-)
NZO/HlLtJ ENSMUSG00225044606
 protein coding gene Chr19:13371196-13382534 (-)
PWK/PhJ ENSLUMG00010007729
 protein coding gene Chr19:8254113-8266093 (-)
SPRET/EiJ ENSMSPG00010044767
 protein coding gene Chr19:8076746-8088083 (-)
WSB/EiJ ENSIUOG00005050496
 protein coding gene Chr19:7823211-7834567 (-)



Homology
more
  • Human Ortholog
    MS4A3, membrane spanning 4-domains A3
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MS4A3, membrane spanning 4-domains A3
  • Synonyms
    CD20L, HTM4
  • Links
    NCBI Gene ID: 932
    UniProt: Q96HJ5

  • Chr Location
    11q12.1; chr11:60056587-60071115 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    87 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    718
  • Tissues
    89
  • cDNA Data
    12
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 170813 NCBI Gene Model | MGI Sequence Detail 11353 C57BL/6J ±  kb
    transcript NM_133246 RefSeq | MGI Sequence Detail 1009 C57BL/6  
    polypeptide Q920C4 UniProt | EBI | MGI Sequence Detail 213 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 12
      Antibodies 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 109
      Developmental Gene Expression 3
      Gene Ontology 5
      Phenotypes 87
    • Earliest
      J:68334 Liang Y, et al., Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse. Genomics. 2001 Mar 1;72(2):119-27
    • Latest
      J:391718 Han J, et al., Two differentiation pathways generate large peritoneal macrophages with one replenishing mesothelial border macrophages. Sci Immunol. 2026 Jul 31;11(121):eaeg8653
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory