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Gphb5 Gene Detail
Summary
  • Symbol
    Gphb5
  • Name
    glycoprotein hormone beta 5
  • Synonyms
    Gpb5, OGH, Zlut1
Location &
Maps
more
  • Sequence Map
    Chr12:75458496-75463555 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 32.71 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    253 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2156540
 protein coding gene Chr12:75458494-75463555 (-)
129S1/SvImJ ENSMUSG00200032004
 protein coding gene Chr12:67403963-67409020 (-)
A/J ENSMUSG00195012868
 protein coding gene Chr12:70115792-70120851 (-)
AKR/J ENSMUSG00220014913
 protein coding gene Chr12:67881964-67887021 (-)
BALB/cJ ENSMUSG00180029653
 protein coding gene Chr12:69076621-69081681 (-)
C3H/HeJ ENSMUSG00175035045
 protein coding gene Chr12:72235568-72240629 (-)
C57BL/6NJ ENSMUSG00215024964
 protein coding gene Chr12:68454932-68459991 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017854
 protein coding gene Chr12:69947589-69952564 (-)
CAST/EiJ ENSTCUG00005031974
 protein coding gene Chr12:68427200-68432255 (-)
CBA/J ENSMUSG00210029348
 protein coding gene Chr12:68663054-68668113 (-)
DBA/2J ENSMUSG00185039207
 protein coding gene Chr12:70535097-70540154 (-)
FVB/NJ ENSMUSG00205016978
 protein coding gene Chr12:68278717-68283761 (-)
JF1/MsJ ENSUMUG00000009433
 protein coding gene Chr12:74561814-74566890 (-)
LP/J ENSMUSG00230017447
 protein coding gene Chr12:77527781-77532838 (-)
NOD/ShiLtJ ENSMUSG00190012155
 protein coding gene Chr12:67714436-67719493 (-)
NZO/HlLtJ ENSMUSG00225038071
 protein coding gene Chr12:79588863-79593924 (-)
PWK/PhJ ENSLUMG00010031132
 protein coding gene Chr12:68587660-68592724 (-)
SPRET/EiJ ENSMSPG00010023616
 protein coding gene Chr12:70352902-70357754 (-)
WSB/EiJ ENSIUOG00005011893
 protein coding gene Chr12:68349012-68354077 (-)



Homology
more
  • Human Ortholog
    GPHB5, glycoprotein hormone subunit beta 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPHB5, glycoprotein hormone subunit beta 5
  • Synonyms
    B5, GPB5, ZLUT1
  • Links
    NCBI Gene ID: 122876
    UniProt: Q86YW7

  • Chr Location
    14q23.2; chr14:63312835-63318935 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice do not display any gross malformations and have normal body weight, composition, and metabolic parameters.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048982 Ensembl Gene Model | MGI Sequence Detail 5060 C57BL/6J ±  kb
    transcript ENSMUST00000051079 Ensembl | MGI Sequence Detail 1612 Not Applicable  
    polypeptide ENSMUSP00000061488 Ensembl | MGI Sequence Detail 130 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 1
    References
    more
    • Summaries
      All 30
      Gene Ontology 6
      Phenotypes 11
    • Earliest
      J:96633 Macdonald LE, et al., Resistance to diet-induced obesity in mice globally overexpressing OGH/GPB5. Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2496-501
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory