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Kcnh4 Gene Detail
Summary
  • Symbol
    Kcnh4
  • Name
    potassium voltage-gated channel, subfamily H (eag-related), member 4
  • Synonyms
    BEC2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2156184
    NCBI Gene: 380728
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100631202-100650768 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 63.57 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    403 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2156184
 protein coding gene Chr11:100631202-100650941 (-)
129S1/SvImJ ENSMUSG00200050710
 protein coding gene Chr11:97901953-97921525 (-)
A/J ENSMUSG00195051522
 protein coding gene Chr11:97595613-97615242 (-)
AKR/J ENSMUSG00220048494
 protein coding gene Chr11:97831742-97851400 (-)
BALB/cJ ENSMUSG00180044087
 protein coding gene Chr11:97963820-97983391 (-)
C3H/HeJ ENSMUSG00175040682
 protein coding gene Chr11:97875522-97895096 (-)
C57BL/6NJ ENSMUSG00215051592
 protein coding gene Chr11:97451009-97470575 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017185
 protein coding gene Chr11:96608279-96627372 (-)
CAST/EiJ ENSTCUG00005046266
 protein coding gene Chr11:97374061-97393785 (-)
CBA/J ENSMUSG00210051539
 protein coding gene Chr11:97597120-97616687 (-)
DBA/2J ENSMUSG00185042265
 protein coding gene Chr11:97925395-97944965 (-)
FVB/NJ ENSMUSG00205045070
 protein coding gene Chr11:97781961-97801529 (-)
JF1/MsJ ENSUMUG00000046231
 protein coding gene Chr11:98177243-98196873 (-)
LP/J ENSMUSG00230046487
 protein coding gene Chr11:98978095-98997666 (-)
NOD/ShiLtJ ENSMUSG00190047635
 protein coding gene Chr11:97961482-97981048 (-)
NZO/HlLtJ ENSMUSG00225051959
 protein coding gene Chr11:101013926-101033497 (-)
PWK/PhJ ENSLUMG00010049529
 protein coding gene Chr11:97726497-97746149 (-)
SPRET/EiJ ENSMSPG00010049752
 protein coding gene Chr11:98219350-98238042 (-)
WSB/EiJ ENSIUOG00005050112
 protein coding gene Chr11:97726469-97746046 (-)



Homology
more
  • Human Ortholog
    KCNH4, potassium voltage-gated channel subfamily H member 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNH4, potassium voltage-gated channel subfamily H member 4
  • Synonyms
    BEC2, ELK1, Kv12.3
  • Links
    NCBI Gene ID: 23415
    UniProt: Q9UQ05

  • Chr Location
    17q21.2; chr17:42156891-42181142 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000035355 Ensembl Gene Model | MGI Sequence Detail 19567 C57BL/6J ±  kb
transcript ENSMUST00000107361 Ensembl | MGI Sequence Detail 3748 Not Applicable  
polypeptide ENSMUSP00000102984 Ensembl | MGI Sequence Detail 1018 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR000595 Cyclic nucleotide-binding domain
    IPR018490 Cyclic nucleotide-binding domain superfamily
    IPR005821 Ion transport domain
    IPR001610 PAC motif
    IPR000700 PAS-associated, C-terminal
    IPR000014 PAS domain
    IPR035965 PAS domain superfamily
    IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG-like
    IPR050818 Potassium channel, voltage-dependent, EAG/ELK/ERG-like, animal-type
    IPR003950 Potassium channel, voltage-dependent, ELK
    IPR014710 PpnP-like, jelly roll fold
  • GlyGen
    A2A5F7 3 sites
Molecular
Reagents
less
  • All nucleic 5
    cDNA 5

    Microarray probesets 1
References
more
  • Summaries
    All 32
    Gene Ontology 4
    Phenotypes 16
  • Earliest
    J:50799 Liu P, et al., Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11. Genetics. 1998 Nov;150(3):1155-68
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory