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Plxnb2 Gene Detail
Summary
  • Symbol
    Plxnb2
  • Name
    plexin B2
  • Synonyms
    1110007H23Rik, Debt, mKIAA0315
  • Feature Type
    protein coding gene
  • IDs
    MGI:2154239
    NCBI Gene: 140570
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:89039752-89064960 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 44.68 cM, cytoband E3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    417 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2154239
 protein coding gene Chr15:89039752-89064991 (-)
129S1/SvImJ ENSMUSG00200034505
 protein coding gene Chr15:86191086-86216975 (-)
A/J ENSMUSG00195017060
 protein coding gene Chr15:86113018-86138896 (-)
AKR/J ENSMUSG00220027388
 protein coding gene Chr15:86143609-86169484 (-)
BALB/cJ ENSMUSG00180014479
 protein coding gene Chr15:85966848-85992724 (-)
C3H/HeJ ENSMUSG00175025330
 protein coding gene Chr15:86299665-86325539 (-)
C57BL/6NJ ENSMUSG00215014086
 protein coding gene Chr15:86060386-86086262 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020156
 protein coding gene Chr15:83102253-83128103 (-)
CAST/EiJ ENSTCUG00005028611
 protein coding gene Chr15:85567292-85593191 (-)
CBA/J ENSMUSG00210012985
 protein coding gene Chr15:86069117-86094990 (-)
DBA/2J ENSMUSG00185020980
 protein coding gene Chr15:86081028-86106903 (-)
FVB/NJ ENSMUSG00205029083
 protein coding gene Chr15:85841776-85867649 (-)
JF1/MsJ ENSUMUG00000032019
 protein coding gene Chr15:85648471-85674615 (-)
LP/J ENSMUSG00230040171
 protein coding gene Chr15:89431271-89457160 (-)
NOD/ShiLtJ ENSMUSG00190024222
 protein coding gene Chr15:86085527-86111423 (-)
NZO/HlLtJ ENSMUSG00225049486
 protein coding gene Chr15:89748142-89774016 (-)
PWK/PhJ ENSLUMG00010032803
 protein coding gene Chr15:85801572-85827499 (-)
SPRET/EiJ ENSMSPG00010012515
 protein coding gene Chr15:87498173-87523380 (-)
WSB/EiJ ENSIUOG00005010561
 protein coding gene Chr15:86175940-86201849 (-)



Homology
more
  • Human Ortholog
    PLXNB2, plexin B2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLXNB2, plexin B2
  • Synonyms
    dJ402G11.3, lncFAL, MM1, Nbla00445, PLEXB2
  • Links
    NCBI Gene ID: 23654
    UniProt: O15031

  • Chr Location
    22q13.33; chr22:50274978-50307695 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    57 phenotypes from 6 alleles in 10 genetic backgrounds
    20 phenotypes from multigenic genotypes
    4 images
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted mutation of this gene die perinatally of exencephaly or survive and seem normal despite severe abnormalities in cerebellar layering and foliation; the external granule cell layer is disorganized due to continued proliferation and migration of differentiated granule cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    921
  • Tissues
    153
  • cDNA Data
    393
  • Literature Summary
    33
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 140570 NCBI Gene Model | MGI Sequence Detail 25209 C57BL/6J ±  kb
    transcript NM_001416431 RefSeq | MGI Sequence Detail 6685 ZRU/MplStud  
    polypeptide B2RXS4 UniProt | EBI | MGI Sequence Detail 1842 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 402
      cDNA 395
      Primer pair 3
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-37143, MGI:108106, MGI:1921090
    References
    more
    • Summaries
      All 132
      Developmental Gene Expression 33
      Diseases 1
      Gene Ontology 14
      Phenotypes 61
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory