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Scgb3a2 Gene Detail
Summary
  • Symbol
    Scgb3a2
  • Name
    secretoglobin, family 3A, member 2
  • Synonyms
    LuLeu1, UGRP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153470
    NCBI Gene: 117158
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:43897354-43900464 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 23.49 cM, cytoband C-D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    246 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2153470
 protein coding gene Chr18:43897346-43900464 (+)
129S1/SvImJ ENSMUSG00200028894
 protein coding gene Chr18:40936113-40939224 (+)
A/J ENSMUSG00195024500
 protein coding gene Chr18:41094652-41097763 (+)
AKR/J ENSMUSG00220020536
 protein coding gene Chr18:41054294-41057405 (+)
BALB/cJ ENSMUSG00180007042
 protein coding gene Chr18:41545821-41548932 (+)
C3H/HeJ ENSMUSG00175010945
 protein coding gene Chr18:41046818-41049929 (+)
C57BL/6NJ ENSMUSG00215008237
 protein coding gene Chr18:40776173-40779283 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022235
 protein coding gene Chr18:40804800-40807921 (+)
CAST/EiJ ENSTCUG00005012978
 protein coding gene Chr18:40632957-40636068 (+)
CBA/J ENSMUSG00210022415
 protein coding gene Chr18:41111582-41114693 (+)
DBA/2J ENSMUSG00185028052
 protein coding gene Chr18:41020273-41023384 (+)
FVB/NJ ENSMUSG00205013002
 protein coding gene Chr18:40662787-40665898 (+)
JF1/MsJ ENSUMUG00000022856
 protein coding gene Chr18:41168973-41172087 (+)
LP/J ENSMUSG00230027941
 protein coding gene Chr18:43125767-43128878 (+)
NOD/ShiLtJ ENSMUSG00190023661
 protein coding gene Chr18:40788998-40792108 (+)
NZO/HlLtJ ENSMUSG00225027400
 protein coding gene Chr18:42997403-43000513 (+)
PWK/PhJ ENSLUMG00010020897
 protein coding gene Chr18:41262030-41265147 (+)
SPRET/EiJ ENSMSPG00010012084
 protein coding gene Chr18:41391080-41394207 (+)
WSB/EiJ ENSIUOG00005008738
 protein coding gene Chr18:40751211-40754322 (+)



Homology
more
  • Human Ortholog
    SCGB3A2, secretoglobin family 3A member 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SCGB3A2, secretoglobin family 3A member 2
  • Synonyms
    LU103, pnSP-1, PNSP1, UGRP1
  • Links
    NCBI Gene ID: 117156
    UniProt: Q96PL1

  • Chr Location
    5q32; chr5:147869800-147882197 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human SCGB3A2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 4 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit background sensitive lung inflammatory response to ovalbumin exposure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    737
  • Tissues
    59
  • cDNA Data
    13
  • Literature Summary
    31
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038791 Ensembl Gene Model | MGI Sequence Detail 3111 C57BL/6J ±  kb
    transcript ENSMUST00000043803 Ensembl | MGI Sequence Detail 842 Not Applicable  
    polypeptide ENSMUSP00000038872 Ensembl | MGI Sequence Detail 139 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 3
      cDNA 13
      Primer pair 9
      Other 1
      Antibodies 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 31
      Gene Ontology 5
      Phenotypes 9
    • Earliest
      J:72388 Niimi T, et al., UGRP1, a Uteroglobin/Clara Cell Secretory Protein-Related Protein, Is a Novel Lung-Enriched Downstream Target Gene for the T/EBP/NKX2.1 Homeodomain Transcription Factor. Mol Endocrinol. 2001 Nov;15(11):2021-36
    • Latest
      J:354192 He H, et al., PRDM3/16 regulate chromatin accessibility required for NKX2-1 mediated alveolar epithelial differentiation and function. Nat Commun. 2024 Sep 16;15(1):8112
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory