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Cd300c2 Gene Detail
Summary
  • Symbol
    Cd300c2
  • Name
    CD300C molecule 2
  • Synonyms
    AF251705, Cd300d, Clm4, DIgR1, Igsf7, LMIR2, MAIR-II
  • Feature Type
    protein coding gene
  • IDs
    MGI:2153249
    NCBI Gene: 140497
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:114887595-114892706 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 80.57 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    336 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2153249
 protein coding gene Chr11:114887547-114895058 (-)
129S1/SvImJ ENSMUSG00200050589
 protein coding gene Chr11:112234724-112239961 (-)
A/J ENSMUSG00195019677
 protein coding gene Chr11:111964494-111969999 (-)
AKR/J ENSMUSG00220032174
 protein coding gene Chr11:112059746-112065004 (-)
BALB/cJ ENSMUSG00180045227
 protein coding gene Chr11:112257134-112262377 (-)
C3H/HeJ ENSMUSG00175043745
 protein coding gene Chr11:112216430-112221935 (-)
C57BL/6NJ ENSMUSG00215009387
 protein coding gene Chr11:111735513-111740675 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017380
 protein coding gene Chr11:110743855-110747898 (+)
CAST/EiJ ENSTCUG00005036058
 protein coding gene Chr11:111648618-111654591 (-)
CBA/J ENSMUSG00210013697
 protein coding gene Chr11:111936656-111942148 (-)
DBA/2J ENSMUSG00185023312
 protein coding gene Chr11:112249414-112254620 (-)
FVB/NJ ENSMUSG00205030193
 protein coding gene Chr11:112082583-112087791 (-)
JF1/MsJ ENSUMUG00000049469
 protein coding gene Chr11:112536248-112541668 (-)
LP/J ENSMUSG00230050053
 protein coding gene Chr11:113310267-113315738 (-)
NOD/ShiLtJ ENSMUSG00190041958
 protein coding gene Chr11:112248379-112253625 (-)
NZO/HlLtJ ENSMUSG00225051795
 protein coding gene Chr11:115348256-115353496 (-)
PWK/PhJ ENSLUMG00010015068
 protein coding gene Chr11:112054294-112059749 (-)
SPRET/EiJ ENSMSPG00010034365
 protein coding gene Chr11:112568241-112573551 (-)
WSB/EiJ ENSIUOG00005044744
 protein coding gene Chr11:112008058-112013549 (-)



Homology
more
  • Human Ortholog
    CD300C, CD300c molecule
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD300C, CD300c molecule
  • Synonyms
    CLM-6, CMRF-35, CMRF35, CMRF-35A, CMRF35A, CMRF35-A1, CMRF35A1, IGSF16, LIR
  • Links
    NCBI Gene ID: 10871
    UniProt: Q08708

  • Chr Location
    17q25.1; chr17:74534362-74546133 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit increased stimulated B cell proliferation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    17
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 140497 NCBI Gene Model | MGI Sequence Detail 5112 C57BL/6J ±  kb
transcript NM_134158 RefSeq | MGI Sequence Detail 933 C57BL/6  
polypeptide Q7TSN2 UniProt | EBI | MGI Sequence Detail 228 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 17

    Microarray probesets 3
References
more
  • Summaries
    All 34
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:71672 Luo K, et al., DIgR1, a novel membrane receptor of the immunoglobulin gene superfamily, is preferentially expressed by antigen-presenting cells. Biochem Biophys Res Commun. 2001 Sep 14;287(1):35-41
  • Latest
    J:282070 Nakazawa Y, et al., Cutting Edge: Involvement of the Immunoreceptor CD300c2 on Alveolar Macrophages in Bleomycin-Induced Lung Fibrosis. J Immunol. 2019 Dec 15;203(12):3107-3111
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory