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Prss28 Gene Detail
Summary
  • Symbol
    Prss28
  • Name
    serine protease 28
  • Synonyms
    Isp1, mIsp-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2149951
    NCBI Gene: 114661
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:25527620-25530850 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 12.53 cM, cytoband A3.3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    231 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2149951
 protein coding gene Chr17:25527617-25530852 (+)
129S1/SvImJ ENSMUSG00200051788
 protein coding gene Chr17:20970788-20974024 (+)
A/J ENSMUSG00195054306
 protein coding gene Chr17:21988516-21991752 (+)
AKR/J ENSMUSG00220044259
 protein coding gene Chr17:21035239-21038475 (+)
BALB/cJ ENSMUSG00180043095
 protein coding gene Chr17:21268781-21272017 (+)
C3H/HeJ ENSMUSG00175051499
 protein coding gene Chr17:21027453-21030689 (+)
C57BL/6NJ ENSMUSG00215050420
 protein coding gene Chr17:21035927-21039156 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021232
 protein coding gene Chr17:21141036-21144266 (+)
CAST/EiJ ENSTCUG00005044373
 protein coding gene Chr17:21612318-21615568 (+)
CBA/J ENSMUSG00210039788
 protein coding gene Chr17:20866259-20869495 (+)
DBA/2J ENSMUSG00185038796
 protein coding gene Chr17:23076837-23080073 (+)
FVB/NJ ENSMUSG00205050607
 protein coding gene Chr17:21331826-21335062 (+)
JF1/MsJ ENSUMUG00000046888
 protein coding gene Chr17:22527467-22530697 (+)
LP/J ENSMUSG00230054503
 protein coding gene Chr17:24475385-24478621 (+)
NOD/ShiLtJ ENSMUSG00190033578
 protein coding gene Chr17:20965579-20968815 (+)
NZO/HlLtJ ENSMUSG00225050757
 protein coding gene Chr17:26395949-26399185 (+)
PWK/PhJ ENSLUMG00010053252
 protein coding gene Chr17:20444746-20447981 (+)
SPRET/EiJ ENSMSPG00010040552
 protein coding gene Chr17:21771575-21774829 (+)
WSB/EiJ ENSIUOG00005051195
 protein coding gene Chr17:21709627-21712864 (+)



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    5 phenotype references
Mice homozygous for a null allele exhibit normal fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    646
  • Tissues
    33
  • cDNA Data
    7
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 114661 NCBI Gene Model | MGI Sequence Detail 3231 C57BL/6J ±  kb
transcript NM_053259 RefSeq | MGI Sequence Detail 1190 C57BL/6  
polypeptide Q924N9 UniProt | EBI | MGI Sequence Detail 274 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 7
    Primer pair 4
    Other 1

    Microarray probesets 2
References
more
  • Summaries
    All 31
    Developmental Gene Expression 5
    Gene Ontology 5
    Phenotypes 5
  • Earliest
    J:71427 O'Sullivan CM, et al., A novel murine tryptase involved in blastocyst hatching and outgrowth. Reproduction. 2001 Jul;122(1):61-71
  • Latest
    J:307642 Dhakal P, et al., Generation and analysis of Prss28 and Prss29 deficient mice using CRISPR-Cas9 genome-editing. Mol Reprod Dev. 2021 May 10;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory