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Npnt Gene Detail
Summary
  • Symbol
    Npnt
  • Name
    nephronectin
  • Synonyms
    1110009H02Rik, POEM
  • Feature Type
    protein coding gene
  • IDs
    MGI:2148811
    NCBI Gene: 114249
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:132587506-132656052 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 61.52 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2217 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2148811
 protein coding gene Chr3:132587506-132656052 (-)
129S1/SvImJ ENSMUSG00200003498
 protein coding gene Chr3:129362704-129431420 (-)
A/J ENSMUSG00195008148
 protein coding gene Chr3:129468930-129537470 (-)
AKR/J ENSMUSG00220021955
 protein coding gene Chr3:127909339-127977890 (-)
BALB/cJ ENSMUSG00180003524
 protein coding gene Chr3:129397816-129466352 (-)
C3H/HeJ ENSMUSG00175013200
 protein coding gene Chr3:128971561-129040109 (-)
C57BL/6NJ ENSMUSG00215017585
 protein coding gene Chr3:129743146-129811696 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025646
 protein coding gene Chr3:126313384-126382485 (-)
CAST/EiJ ENSTCUG00005003394
 protein coding gene Chr3:130066392-130135196 (-)
CBA/J ENSMUSG00210003921
 protein coding gene Chr3:129589322-129657876 (-)
DBA/2J ENSMUSG00185025795
 protein coding gene Chr3:130206640-130275347 (-)
FVB/NJ ENSMUSG00205021155
 protein coding gene Chr3:128525439-128593988 (-)
JF1/MsJ ENSUMUG00000013564
 protein coding gene Chr3:128951512-129025277 (-)
LP/J ENSMUSG00230003454
 protein coding gene Chr3:132181174-132249869 (-)
NOD/ShiLtJ ENSMUSG00190001184
 protein coding gene Chr3:130585994-130654531 (-)
NZO/HlLtJ ENSMUSG00225004444
 protein coding gene Chr3:134622735-134691404 (-)
PWK/PhJ ENSLUMG00010014854
 protein coding gene Chr3:128948637-129015909 (-)
SPRET/EiJ ENSMSPG00010012570
 protein coding gene Chr3:129977300-130044037 (-)
WSB/EiJ ENSIUOG00005016443
 protein coding gene Chr3:129732637-129801164 (-)



Homology
more
  • Human Ortholog
    NPNT, nephronectin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NPNT, nephronectin
  • Synonyms
    EGFL6L, POEM
  • Links
    NCBI Gene ID: 255743
    UniProt: Q6UXI9

  • Chr Location
    4q24; chr4:105894775-106004027 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Npnt mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele frequently exhibit kidney agenesis or hypoplasia attributed to a delay in the invasion of the metanephric mesenchyme by the ureteric bud at an early stage of kidney development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1164
  • Tissues
    254
  • cDNA Data
    22
  • Literature Summary
    31
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 114249 NCBI Gene Model | MGI Sequence Detail 68547 C57BL/6J ±  kb
    transcript NM_001287101 RefSeq | MGI Sequence Detail 4763 C57BL/6  
    polypeptide Q91V88 UniProt | EBI | MGI Sequence Detail 561 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 23
      Primer pair 7
      Other 3
      Antibodies 5

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1915250, MGI:2139604, MGI:2139662
    References
    more
    • Summaries
      All 81
      Developmental Gene Expression 31
      Diseases 2
      Gene Ontology 11
      Phenotypes 23
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:388029 Garis MR, et al., Nephronectin Promotes Migration of the Periocular Mesenchyme via EGFR Signaling. Invest Ophthalmol Vis Sci. 2026 Jun 1;67(6):40
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory