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Acaa1a Gene Detail
Summary
  • Symbol
    Acaa1a
  • Name
    acetyl-Coenzyme A acyltransferase 1A
  • Synonyms
    Acaa1, D9Ertd25e, MGC:7090, peroxisomal 3-ketoacyl-CoA thiolase, PTL, thiolase A
  • Feature Type
    protein coding gene
  • IDs
    MGI:2148491
    NCBI Gene: 113868
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:119170113-119179361 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 71.33 cM, cytoband F4
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    330 from dbSNP Build 142
  • Strain Annotations
    21
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2148491
 protein coding gene Chr9:119168742-119179365 (+)
129S1/SvImJ ENSMUSG00200028692
 protein coding gene Chr9:116289239-116298245 (+)
A/J ENSMUSG00195026797
 protein coding gene Chr9:115471294-115480351 (+)
AKR/J ENSMUSG00220019102
 protein coding gene Chr9:115928249-115937316 (+)
BALB/cJ ENSMUSG00180028986
 protein coding gene Chr9:116008659-116017718 (+)
C3H/HeJ ENSMUSG00175018556
 protein coding gene Chr9:116251953-116261010 (+)
C57BL/6NJ ENSMUSGG00215055758
 protein coding gene Chr9:116122563-116123928 (+)
C57BL/6NJ ENSMUSG00215027026
 protein coding gene Chr9:116123949-116131209 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032799
 protein coding gene Chr9:114758228-114768818 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210040393
 protein coding gene Chr9:115967200-115976267 (+)
DBA/2J ENSMUSG00185015831
 protein coding gene Chr9:116301449-116310514 (+)
FVB/NJ ENSMUSG00205027462
 protein coding gene Chr9:116140151-116149208 (+)
JF1/MsJ ENSUMUG00000025947
 protein coding gene Chr9:116161412-116170179 (+)
LP/J ENSMUSG00230036987
 protein coding gene Chr9:116419086-116426346 (+)
LP/J ENSMUSGG00230055512
 protein coding gene Chr9:116417700-116419065 (+)
NOD/ShiLtJ ENSMUSGG00190054545
 protein coding gene Chr9:115901089-115902454 (+)
NOD/ShiLtJ ENSMUSG00190013022
 protein coding gene Chr9:115902475-115909735 (+)
NZO/HlLtJ ENSMUSG00225022832
 protein coding gene Chr9:116684207-116693212 (+)
PWK/PhJ ENSLUMG00010031650
 protein coding gene Chr9:116063834-116072549 (+)
SPRET/EiJ ENSMSPG00010020747
 protein coding gene Chr9:117764402-117773371 (+)
WSB/EiJ ENSIUOG00005019885
 protein coding gene Chr9:115353857-115362922 (+)



Homology
more
  • Human Ortholog
    ACAA1, acetyl-CoA acyltransferase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACAA1, acetyl-CoA acyltransferase 1
  • Synonyms
    ACAA, Lnc-Myd88, PTHIO, THIO
  • Links
    NCBI Gene ID: 30
    UniProt: P09110

  • Chr Location
    3p22.2; chr3:38103129-38137647 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    4 phenotypes from multigenic genotypes
    10 phenotype references
Mice heterozygous for a knock-out allele show no apparent phenotype under normal conditions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    861
  • Tissues
    121
  • cDNA Data
    186
  • Literature Summary
    8
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 113868 NCBI Gene Model | MGI Sequence Detail 9249 C57BL/6J ±  kb
transcript NM_001421420 RefSeq | MGI Sequence Detail 1778 C57BL/6  
polypeptide Q921H8 UniProt | EBI | MGI Sequence Detail 424 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 191
    cDNA 188
    Primer pair 2
    Other 1
    Antibodies 3

    Microarray probesets 6
Other
Accession IDs
less
MGI:1098606
References
more
  • Summaries
    All 59
    Developmental Gene Expression 8
    Gene Ontology 15
    Phenotypes 10
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:371968 Lee H, et al., ACAA1 knockout increases the survival rate of KPC mice by activating autophagy. Mol Metab. 2025 Oct;100:102237
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory