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Pkdcc Gene Detail
Summary
  • Symbol
    Pkdcc
  • Name
    protein kinase domain containing, cytoplasmic
  • Synonyms
    Adtk1, ESTM17, MAd1, Vlk
  • Feature Type
    protein coding gene
  • IDs
    MGI:2147077
    NCBI Gene: 106522
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:83522721-83532499 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 52.25 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    300 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2147077
 protein coding gene Chr17:83522708-83532499 (+)
129S1/SvImJ ENSMUSG00200024532
 protein coding gene Chr17:78910084-78919830 (+)
A/J ENSMUSG00195026133
 protein coding gene Chr17:80283395-80293152 (+)
AKR/J ENSMUSG00220013277
 protein coding gene Chr17:79240893-79250668 (+)
BALB/cJ ENSMUSG00180004788
 protein coding gene Chr17:79965943-79975720 (+)
C3H/HeJ ENSMUSG00175015640
 protein coding gene Chr17:79221978-79231731 (+)
C57BL/6NJ ENSMUSG00215013091
 protein coding gene Chr17:78959515-78969293 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021915
 protein coding gene Chr17:78800953-78810649 (+)
CAST/EiJ ENSTCUG00005015015
 protein coding gene Chr17:79755331-79765097 (+)
CBA/J ENSMUSG00210019757
 protein coding gene Chr17:79080686-79090433 (+)
DBA/2J ENSMUSG00185019343
 protein coding gene Chr17:81901222-81910985 (+)
FVB/NJ ENSMUSG00205022247
 protein coding gene Chr17:79727118-79736877 (+)
JF1/MsJ ENSUMUG00000010505
 protein coding gene Chr17:81639395-81649157 (+)
LP/J ENSMUSG00230009434
 protein coding gene Chr17:82928218-82938016 (+)
NOD/ShiLtJ ENSMUSG00190009347
 protein coding gene Chr17:78993538-79003332 (+)
NZO/HlLtJ ENSMUSG00225030884
 protein coding gene Chr17:85190014-85199777 (+)
PWK/PhJ ENSLUMG00010004964
 protein coding gene Chr17:78844287-78854058 (+)
SPRET/EiJ ENSMSPG00010008155
 protein coding gene Chr17:79408881-79418611 (+)
WSB/EiJ ENSIUOG00005010238
 protein coding gene Chr17:79916259-79926038 (+)



Homology
more
  • Human Ortholog
    PKDCC, protein kinase domain containing, cytoplasmic
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PKDCC, protein kinase domain containing, cytoplasmic
  • Synonyms
    RLSDF, SGK493, Vlk
  • Links
    NCBI Gene ID: 91461
    UniProt: Q504Y2

  • Chr Location
    2p21; chr2:42048021-42058525 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PKDCC associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    66 phenotypes from 5 alleles in 5 genetic backgrounds
    9 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants die on postnatal day P0, apparently due to ineffective respiration. They exhibit shortening of all the long bones of the fore- and hindlimbs, cleft palate, sternal dysraphia and deficient mineralization or other anomalies of multiple bones throughout the body.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    815
  • Tissues
    110
  • cDNA Data
    65
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024247 Ensembl Gene Model | MGI Sequence Detail 9779 C57BL/6J ±  kb
    transcript ENSMUST00000170794 Ensembl | MGI Sequence Detail 2446 Not Applicable  
    polypeptide ENSMUSP00000129238 Ensembl | MGI Sequence Detail 492 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 75
      cDNA 65
      Primer pair 8
      Other 2
      Antibodies 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-28126, MGI:104832, MGI:2146795
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 15
      Gene Ontology 13
      Phenotypes 14
    • Earliest
      J:28401 Bettenhausen B, et al., Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
    • Latest
      J:375914 Srikanth KD, et al., The synaptic ectokinase VLK triggers the EphB2-NMDAR interaction to drive injury-induced pain. Science. 2025 Nov 20;390(6775):eadp1007
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory