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Lmf2 Gene Detail
Summary
  • Symbol
    Lmf2
  • Name
    lipase maturation factor 2
  • Synonyms
    Tmem112b, Tmem153
  • Feature Type
    protein coding gene
  • IDs
    MGI:2146015
    NCBI Gene: 105847
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:89235207-89239862 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 44.84 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    145 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2146015
 protein coding gene Chr15:89235203-89239862 (-)
129S1/SvImJ ENSMUSG00200035131
 protein coding gene Chr15:86387366-86392021 (-)
A/J ENSMUSG00195019502
 protein coding gene Chr15:86308796-86313451 (-)
AKR/J ENSMUSG00220028776
 protein coding gene Chr15:86339371-86344026 (-)
BALB/cJ ENSMUSG00180013821
 protein coding gene Chr15:86162596-86167251 (-)
C3H/HeJ ENSMUSG00175025448
 protein coding gene Chr15:86495397-86500052 (-)
C57BL/6NJ ENSMUSG00215021126
 protein coding gene Chr15:86256141-86260796 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020162
 protein coding gene Chr15:83306316-83310969 (-)
CAST/EiJ ENSTCUG00005028970
 protein coding gene Chr15:85760795-85765450 (-)
CBA/J ENSMUSG00210013001
 protein coding gene Chr15:86264840-86269495 (-)
DBA/2J ENSMUSG00185021860
 protein coding gene Chr15:86276776-86281431 (-)
FVB/NJ ENSMUSG00205023182
 protein coding gene Chr15:86037498-86042153 (-)
JF1/MsJ ENSUMUG00000037799
 protein coding gene Chr15:85843941-85848596 (-)
LP/J ENSMUSG00230042556
 protein coding gene Chr15:89627560-89632215 (-)
NOD/ShiLtJ ENSMUSG00190026922
 protein coding gene Chr15:86281255-86285910 (-)
NZO/HlLtJ ENSMUSG00225049345
 protein coding gene Chr15:89943873-89948528 (-)
PWK/PhJ ENSLUMG00010031306
 protein coding gene Chr15:85996592-86001247 (-)
SPRET/EiJ ENSMSPG00010013560
 protein coding gene Chr15:87698693-87703824 (-)
WSB/EiJ ENSIUOG00005011074
 protein coding gene Chr15:86371528-86376183 (-)



Homology
more
  • Human Ortholog
    LMF2, lipase maturation factor 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LMF2, lipase maturation factor 2
  • Synonyms
    TMEM112B, TMEM153
  • Links
    NCBI Gene ID: 91289
    UniProt: Q9BU23

  • Chr Location
    22q13.33; chr22:50502947-50507732 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotype references
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    4
  • Gene trapped
    2
  • Radiation induced
    2
  • Targeted
    1
  • Genomic Mutations
    3 involving Lmf2
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    21 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    4
  • GO References
    3
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    598
  • Tissues
    1
  • cDNA Data
    99
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022614 Ensembl Gene Model | MGI Sequence Detail 4656 C57BL/6J ±  kb
transcript ENSMUST00000023283 Ensembl | MGI Sequence Detail 2906 Not Applicable  
polypeptide ENSMUSP00000023283 Ensembl | MGI Sequence Detail 702 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000009857 lipase maturation factor 2
    (term hierarchy)
  • InterPro Domains
    IPR009613 Lipase maturation factor
    IPR057433 Lipase maturation factor 1/2, C-terminal domain
    IPR057434 Lipase maturation factor 1/2, N-terminal domain
  • GlyGen
    Q8C3X8 1 site, 1 N-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 99
    cDNA 99

    Microarray probesets 3
References
more
  • Summaries
    All 53
    Developmental Gene Expression 1
    Diseases 1
    Gene Ontology 3
    Phenotypes 27
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory