Cep170b MGI Mouse Gene Detail - MGI:2145043

Symbol

Cep170b
Name

centrosomal protein 170B
Synonyms

AW555464, mKIAA0284

Feature Type

protein coding gene
IDs

MGI:2145043
NCBI Gene: 217882
Alliance

genome feature page
Transcription Start Sites

8 TSS

Sequence Map

Chr12:112687950-112713026 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 61.20 cM
Mapping Data

2 experiments

SNPs within 2kb

684 from dbSNP Build 142
Strain Annotations

26

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_2145043	protein coding gene	Chr12:112686889-112713026 (+)
129S1/SvImJ	ENSMUSG00200025221	protein coding gene	Chr12:104469465-104469554 (+)
129S1/SvImJ	ENSMUSGG00200054694	protein coding gene	Chr12:104476846-104492070 (+)
A/J	ENSMUSG00195044137	protein coding gene	Chr12:106983475-107011296 (+)
AKR/J	ENSMUSG00220031476	protein coding gene	Chr12:104894067-104916432 (+)
BALB/cJ	ENSMUSG00180046510	protein coding gene	Chr12:106238153-106238242 (+)
BALB/cJ	ENSMUSGG00180055017	protein coding gene	Chr12:106245534-106260754 (+)
C3H/HeJ	ENSMUSG00175033653	protein coding gene	Chr12:108810271-108838487 (+)
C57BL/6NJ	ENSMUSGG00215055410	protein coding gene	Chr12:105512973-105528195 (+)
C57BL/6NJ	ENSMUSG00215045639	protein coding gene	Chr12:105505592-105505681 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018158	protein coding gene	Chr12:107182300-107206834 (+)
CAST/EiJ	ENSTCUGG00005054058	protein coding gene	Chr12:104986070-105001004 (+)
CBA/J	ENSMUSGG00210054814	protein coding gene	Chr12:105879161-105894133 (+)
CBA/J	ENSMUSG00210029247	protein coding gene	Chr12:105871775-105871864 (+)
DBA/2J	ENSMUSG00185027554	protein coding gene	Chr12:107689542-107689631 (+)
DBA/2J	ENSMUSGG00185057611	protein coding gene	Chr12:107696923-107712145 (+)
FVB/NJ	ENSMUSG00205032484	protein coding gene	Chr12:104911744-104934102 (+)
JF1/MsJ	ENSUMUGG00000058646	protein coding gene	Chr12:112470771-112485475 (+)
LP/J	ENSMUSGG00230055402	protein coding gene	Chr12:114741325-114756547 (+)
LP/J	ENSMUSG00230043325	protein coding gene	Chr12:114733944-114734033 (+)
NOD/ShiLtJ	ENSMUSG00190028432	protein coding gene	Chr12:80314963-80315052 (-)
NOD/ShiLtJ	ENSMUSGG00190054668	protein coding gene	Chr12:80292449-80307671 (-)
NZO/HlLtJ	ENSMUSG00225042817	protein coding gene	Chr12:116483556-116511630 (+)
PWK/PhJ	ENSLUMG00010039097	protein coding gene	Chr12:105908265-105937078 (+)
SPRET/EiJ	ENSMSPG00010016545	protein coding gene	Chr12:108193761-108219566 (+)
WSB/EiJ	ENSIUOG00005035082	protein coding gene	Chr12:104896062-104923873 (+)

Human Ortholog

CEP170B, centrosomal protein 170B

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CEP170B, centrosomal protein 170B
Synonyms

CEP170R, FAM68C, KIAA0284
Links

HGNC:20362

NCBI Gene ID: 283638

UniProt: Q9Y4F5
Chr Location

14q32.33; chr14:104864513-104896770 (+) GRCh38

MGI Vertebrate Homology

Cep170b stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CEP170B
Gene Tree

Cep170b

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

5
Gene trapped

1
Targeted

2
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

43 strains or lines available

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All GO Annotations

1
GO References

1

Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

714
Tissues

21
cDNA Data

97
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cep170b

ZFIN cep170bb

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All Sequences

61
RefSeq

6
UniProt

4
CCDS

CCDS56867.1

Ensembl

ENSMUSG00000072825 (Evidence)
NCBI Gene

217882

			Length	Strain/Species	Flank
genomic	217882	NCBI Gene Model \| MGI Sequence Detail	25077	C57BL/6J	± kb
transcript	NM_001024602	RefSeq \| MGI Sequence Detail	6627	ZRU/MplStud
polypeptide	Q80U49	UniProt \| EBI \| MGI Sequence Detail	1574	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000060141 centrosomal protein of 170 kDa protein B

(term hierarchy)
InterPro Domains

IPR051176 Centrosomal and Immune Signaling Modulators

IPR029300 CEP170, C-terminal

IPR000253 Forkhead-associated (FHA) domain

IPR008984 SMAD/FHA domain superfamily
GlyGen

Q80U49 7 sites, 1 N-linked glycan (1 site)

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All nucleic 97

cDNA 97

Microarray probesets 2

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MGI:2445826

Summaries

All 32

Developmental Gene Expression 2

Gene Ontology 1

Phenotypes 9
Earliest

J:75291 Witherden AS, et al., An integrated genetic, radiation hybrid, physical and transcription map of a region of distal mouse chromosome 12, including an imprinted locus and the 'Legs at odd angles' (Loa) mutation. Gene. 2002 Jan 23;283(1-2):71-82
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Cep170b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr115399	Chr12:112687539-112687561 (+)	-400 bp
Tssr115400	Chr12:112687938-112687964 (+)	1 bp
Tssr115401	Chr12:112688263-112688283 (+)	323 bp
Tssr115402	Chr12:112688597-112688673 (+)	685 bp
Tssr115403	Chr12:112688944-112688968 (+)	1,006 bp
Tssr115404	Chr12:112689229-112689255 (+)	1,292 bp
Tssr115405	Chr12:112697553-112697556 (+)	9,605 bp
Tssr115406	Chr12:112697643-112697652 (+)	9,698 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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