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Tecpr2 Gene Detail
Summary
  • Symbol
    Tecpr2
  • Name
    tectonin beta-propeller repeat containing 2
  • Synonyms
    4930573I19Rik, mKIAA0297
  • Feature Type
    protein coding gene
  • IDs
    MGI:2144865
    NCBI Gene: 104859
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:110855698-110938828 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 60.86 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1791 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2144865
 protein coding gene Chr12:110855681-110938828 (+)
129S1/SvImJ ENSMUSG00200024688
 protein coding gene Chr12:102632066-102715212 (+)
A/J ENSMUSG00195043566
 protein coding gene Chr12:105155112-105238306 (+)
AKR/J ENSMUSG00220033886
 protein coding gene Chr12:103048981-103131874 (+)
BALB/cJ ENSMUSG00180044857
 protein coding gene Chr12:104395164-104478299 (+)
C3H/HeJ ENSMUSG00175036352
 protein coding gene Chr12:106964477-107049851 (+)
C57BL/6NJ ENSMUSG00215045405
 protein coding gene Chr12:103668013-103751155 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018123
 protein coding gene Chr12:105336628-105423569 (+)
CAST/EiJ ENSTCUG00005019323
 protein coding gene Chr12:103134985-103218899 (+)
CBA/J ENSMUSG00210028751
 protein coding gene Chr12:104025949-104111323 (+)
DBA/2J ENSMUSG00185026838
 protein coding gene Chr12:105851550-105941276 (+)
FVB/NJ ENSMUSG00205030622
 protein coding gene Chr12:103079939-103163084 (+)
JF1/MsJ ENSUMUG00000019044
 protein coding gene Chr12:110617322-110700951 (+)
LP/J ENSMUSG00230041665
 protein coding gene Chr12:112896691-112979823 (+)
NOD/ShiLtJ ENSMUSG00190021571
 protein coding gene Chr12:82068238-82151128 (-)
NZO/HlLtJ ENSMUSG00225042349
 protein coding gene Chr12:114644881-114728009 (+)
PWK/PhJ ENSLUMG00010039590
 protein coding gene Chr12:104073920-104157292 (+)
SPRET/EiJ ENSMSPG00010017407
 protein coding gene Chr12:106360839-106444022 (+)
WSB/EiJ ENSIUOG00005032978
 protein coding gene Chr12:103063291-103148643 (+)



Homology
more
  • Human Ortholog
    TECPR2, tectonin beta-propeller repeat containing 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TECPR2, tectonin beta-propeller repeat containing 2
  • Synonyms
    HSAN9, KIAA0329, SPG49
  • Links
    NCBI Gene ID: 9895
    UniProt: O15040

  • Chr Location
    14q32.31; chr14:102362941-102502477 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TECPR2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit neurodegeneration, abnormal gait, increased mechanical nociceptive threshold, decreased thermal nociceptive threshold, and impaired autophagy.
Gene Ontology
(GO)
Classifications
less
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

Cellular Component
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    605
  • Tissues
    1
  • cDNA Data
    52
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021275 Ensembl Gene Model | MGI Sequence Detail 83131 C57BL/6J ±  kb
    transcript ENSMUST00000169597 Ensembl | MGI Sequence Detail 7780 Not Applicable  
    polypeptide ENSMUSP00000126749 Ensembl | MGI Sequence Detail 1423 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • InterPro Domains
      IPR006624 Beta-propeller repeat TECPR
      IPR056499 HPS5-like, beta-propeller domain
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 52

      Microarray probesets 3
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 1
      Phenotypes 12
    • Earliest
      J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory