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Tmem11 Gene Detail
Summary
  • Symbol
    Tmem11
  • Name
    transmembrane protein 11
  • Synonyms
    5730466P16Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2144726
    NCBI Gene: 216821
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:60755278-60769864 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 37.90 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    389 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2144726
 protein coding gene Chr11:60755278-60770098 (-)
129S1/SvImJ ENSMUSG00200033576
 protein coding gene Chr11:57675011-57689780 (-)
A/J ENSMUSG00195037810
 protein coding gene Chr11:57708662-57723291 (-)
AKR/J ENSMUSG00220049977
 protein coding gene Chr11:57822490-57837268 (-)
BALB/cJ ENSMUSG00180049288
 protein coding gene Chr11:57767915-57782736 (-)
C3H/HeJ ENSMUSG00175037028
 protein coding gene Chr11:57725960-57740589 (-)
C57BL/6NJ ENSMUSG00215037222
 protein coding gene Chr11:57474692-57489514 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016466
 protein coding gene Chr11:55691091-55705876 (-)
CAST/EiJ ENSTCUG00005042027
 protein coding gene Chr11:57257243-57271872 (-)
CBA/J ENSMUSG00210038384
 protein coding gene Chr11:57558997-57573626 (-)
DBA/2J ENSMUSG00185042765
 protein coding gene Chr11:57754309-57769093 (-)
FVB/NJ ENSMUSG00205050532
 protein coding gene Chr11:57635023-57649750 (-)
JF1/MsJ ENSUMUG00000047963
 protein coding gene Chr11:58158910-58173539 (-)
LP/J ENSMUSG00230049579
 protein coding gene Chr11:58896314-58911083 (-)
NOD/ShiLtJ ENSMUSG00190051135
 protein coding gene Chr11:57749102-57763881 (-)
NZO/HlLtJ ENSMUSG00225044180
 protein coding gene Chr11:61044041-61059907 (-)
PWK/PhJ ENSLUMG00010027373
 protein coding gene Chr11:57678719-57692372 (-)
SPRET/EiJ ENSMSPG00010040750
 protein coding gene Chr11:58351704-58366448 (-)
WSB/EiJ ENSIUOG00005033184
 protein coding gene Chr11:57665517-57680289 (-)



Homology
more
  • Human Ortholog
    TMEM11, transmembrane protein 11
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM11, transmembrane protein 11
  • Synonyms
    C17orf35, PM1, PMI
  • Links
    NCBI Gene ID: 8834
    UniProt: P17152

  • Chr Location
    17p11.2; chr17:21197954-21214595 (-)  GRCh38
Human Diseases
less
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 3 alleles in 3 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit enhanced adult cardiomyocyte proliferation, with increased numbers of and smaller size of cardiomyocytes, and enhanced restoration of heart function after myocardial injury. Another allele shows eye and skin abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    7
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    621
  • Tissues
    15
  • cDNA Data
    8
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 216821 NCBI Gene Model | MGI Sequence Detail 14587 C57BL/6J ±  kb
    transcript NM_001168507 RefSeq | MGI Sequence Detail 1511 C57BL/6  
    polypeptide Q8BK08 UniProt | EBI | MGI Sequence Detail 190 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 4
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 1
      Diseases 2
      Gene Ontology 7
      Phenotypes 32
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:365007 Wu B, et al., Mitochondrial reactive oxygen species regulate acetyl-CoA flux between cytokine production and fatty acid synthesis in effector T cells. Cell Rep. 2025 Mar 25;44(3):115430
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory