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Phldb1 Gene Detail
Summary
  • Symbol
    Phldb1
  • Name
    pleckstrin homology like domain, family B, member 1
  • Synonyms
    D330037A14Rik, LL5A, mKIAA0638
  • Feature Type
    protein coding gene
  • IDs
    MGI:2143230
    NCBI Gene: 102693
  • Alliance
  • Transcription Start Sites
    9 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr9:44597601-44646495 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 24.84 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1281 from dbSNP Build 142
  • Strain Annotations
    25
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2143230
protein coding gene Chr9:44597601-44649800 (-)
129S1/SvImJ ENSMUSGG00200054436
protein coding gene Chr9:41676786-41706212 (-)
A/J ENSMUSGG00195055060
protein coding gene Chr9:41433552-41462870 (-)
A/J ENSMUSG00195023602
protein coding gene Chr9:41463371-41465646 (-)
AKR/J ENSMUSG00220038973
protein coding gene Chr9:41544342-41546617 (-)
AKR/J ENSMUSGG00220054469
protein coding gene Chr9:41514169-41543841 (-)
BALB/cJ ENSMUSGG00180055169
protein coding gene Chr9:41545279-41574591 (-)
BALB/cJ ENSMUSG00180025314
protein coding gene Chr9:41575092-41577367 (-)
C3H/HeJ ENSMUSGG00175054641
protein coding gene Chr9:41557180-41586492 (-)
C3H/HeJ ENSMUSG00175014381
protein coding gene Chr9:41586993-41589268 (-)
C57BL/6NJ ENSMUSG00215028586
protein coding gene Chr9:41547732-41550007 (-)
C57BL/6NJ ENSMUSGG00215055335
protein coding gene Chr9:41517916-41547231 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032124
protein coding gene Chr9:41560917-41610583 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210016619
protein coding gene Chr9:41628046-41630321 (-)
CBA/J ENSMUSGG00210054700
protein coding gene Chr9:41598223-41627545 (-)
DBA/2J ENSMUSGG00185057510
protein coding gene Chr9:41671862-41701174 (-)
DBA/2J ENSMUSG00185009274
protein coding gene Chr9:41701675-41703950 (-)
FVB/NJ ENSMUSGG00205054177
protein coding gene Chr9:41913588-41943259 (-)
FVB/NJ ENSMUSG00205035215
protein coding gene Chr9:41943760-41946035 (-)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055541
protein coding gene Chr9:41967251-41996677 (-)
NOD/ShiLtJ ENSMUSGG00190055024
protein coding gene Chr9:41750831-41780142 (-)
NOD/ShiLtJ ENSMUSG00190021019
protein coding gene Chr9:41780643-41782918 (-)
NZO/HlLtJ ENSMUSGG00225055591
protein coding gene Chr9:41927658-41956973 (-)
NZO/HlLtJ ENSMUSG00225043278
protein coding gene Chr9:41957474-41959749 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010009013
protein coding gene Chr9:42435960-42484599 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    PHLDB1, pleckstrin homology like domain family B member 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PHLDB1, pleckstrin homology like domain family B member 1
  • Synonyms
    LL5A, LL5alpha, OI23
  • Links
    NCBI Gene ID: 23187
    UniProt: Q86UU1

  • Chr Location
    11q23.3; chr11:118606396-118658038 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human PHLDB1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048537 Ensembl Gene Model | MGI Sequence Detail 48895 C57BL/6J ±  kb
    transcript ENSMUST00000138356 Ensembl | MGI Sequence Detail 5600 Not Applicable  
    polypeptide ENSMUSP00000120208 Ensembl | MGI Sequence Detail 1449 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      17 Sequences
    • Protein Ontology
      PR:000030919 pleckstrin homology-like domain family B member 1
    • InterPro Domains
      IPR000253 Forkhead-associated (FHA) domain
      IPR037810 PHLDB1/2/3, PH domain
      IPR011993 PH-like domain superfamily
      IPR001849 Pleckstrin homology domain
      IPR052212 Pleckstrin homology-like domain-containing protein
      IPR008984 SMAD/FHA domain superfamily
    • GlyGen
      Q6PDH0 10 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (9 sites)
    Molecular
    Reagents
    less
    • All nucleic 94
      cDNA 94

      Microarray probesets 4
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 11
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    09/08/2026
    MGI 6.24
    The Jackson Laboratory