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Kctd10 Gene Detail
Summary
  • Symbol
    Kctd10
  • Name
    potassium channel tetramerisation domain containing 10
  • Feature Type
    protein coding gene
  • IDs
    MGI:2141207
    NCBI Gene: 330171
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:114501633-114518566 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 55.99 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    506 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2141207
 protein coding gene Chr5:114501628-114518569 (-)
129S1/SvImJ ENSMUSG00200021012
 protein coding gene Chr5:108242476-108259331 (-)
A/J ENSMUSG00195035755
 protein coding gene Chr5:107755614-107772516 (-)
AKR/J ENSMUSG00220043141
 protein coding gene Chr5:107271797-107288650 (-)
BALB/cJ ENSMUSG00180044150
 protein coding gene Chr5:107893078-107909940 (-)
C3H/HeJ ENSMUSG00175041762
 protein coding gene Chr5:109880903-109897839 (-)
C57BL/6NJ ENSMUSG00215032885
 protein coding gene Chr5:107901989-107918931 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027594
 protein coding gene Chr5:107323133-107341263 (-)
CAST/EiJ ENSTCUG00005022710
 protein coding gene Chr5:107080447-107097144 (-)
CBA/J ENSMUSG00210034709
 protein coding gene Chr5:108632979-108649914 (-)
DBA/2J ENSMUSG00185043062
 protein coding gene Chr5:111678606-111695457 (-)
FVB/NJ ENSMUSG00205051433
 protein coding gene Chr5:107531444-107548386 (-)
JF1/MsJ ENSUMUG00000020517
 protein coding gene Chr5:114523777-114540502 (-)
LP/J ENSMUSG00230043326
 protein coding gene Chr5:115780660-115797510 (-)
NOD/ShiLtJ ENSMUSG00190048103
 protein coding gene Chr5:107570026-107586963 (-)
NZO/HlLtJ ENSMUSG00225014842
 protein coding gene Chr5:123428051-123444901 (-)
PWK/PhJ ENSLUMG00010031517
 protein coding gene Chr5:106427461-106444179 (-)
SPRET/EiJ ENSMSPG00010041525
 protein coding gene Chr5:109710756-109726112 (-)
WSB/EiJ ENSIUOG00005042074
 protein coding gene Chr5:110273390-110290316 (-)



Homology
more
  • Human Ortholog
    KCTD10, potassium channel tetramerization domain containing 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCTD10, potassium channel tetramerization domain containing 10
  • Synonyms
    BTBD28, hBACURD3, MSTP028, ULRO61
  • Links
    NCBI Gene ID: 83892
    UniProt: Q9H3F6

  • Chr Location
    12q24.11; chr12:109448655-109477359 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality between E10.5 and E11.5, abnormal vasculature, absent vitelline circulation, enlarged pericardium, thin myocardium and defective heart valve defect formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    658
  • Tissues
    5
  • cDNA Data
    15
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 330171 NCBI Gene Model | MGI Sequence Detail 16934 C57BL/6J ±  kb
    transcript NM_001159941 RefSeq | MGI Sequence Detail 3098 C57BL/6  
    polypeptide Q922M3 UniProt | EBI | MGI Sequence Detail 315 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000029298 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3
      (term hierarchy)
    • InterPro Domains
      IPR000210 BTB/POZ domain
      IPR045068 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1-3
      IPR063516 KCTD10/TNFAIP1/KCTD13, C-terminal domain
      IPR003131 Potassium channel tetramerisation-type BTB domain
      IPR011333 SKP1/BTB/POZ domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2141336
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 23
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:346633 Cheng J, et al., KCTD10 regulates brain development by destabilizing brain disorder-associated protein KCTD13. Proc Natl Acad Sci U S A. 2024 Mar 19;121(12):e2315707121
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory