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Tyw1 Gene Detail
Summary
  • Symbol
    Tyw1
  • Name
    tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)
  • Synonyms
    Rsafd1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2141161
    NCBI Gene: 100929
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:130284460-130370404 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 69.00 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    2576 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2141161
 protein coding gene Chr5:130284460-130370408 (+)
129S1/SvImJ ENSMUSG00200042087
 protein coding gene Chr5:124029848-124116592 (+)
A/J ENSMUSG00195049409
 protein coding gene Chr5:123572305-123659066 (+)
AKR/J ENSMUSG00220049604
 protein coding gene Chr5:123040541-123127281 (+)
BALB/cJ ENSMUSG00180034340
 protein coding gene Chr5:123679660-123766411 (+)
C3H/HeJ ENSMUSG00175033999
 protein coding gene Chr5:125640113-125726847 (+)
C57BL/6NJ ENSMUSG00215045001
 protein coding gene Chr5:123712970-123799708 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027801
 protein coding gene Chr5:123090756-123178415 (+)
CAST/EiJ ENSTCUG00005009907
 protein coding gene Chr5:122950002-123035612 (+)
CBA/J ENSMUSG00210007129
 protein coding gene Chr5:124390779-124477526 (+)
DBA/2J ENSMUSG00185007173
 protein coding gene Chr5:127442765-127529505 (+)
FVB/NJ ENSMUSG00205042198
 protein coding gene Chr5:123322466-123409147 (+)
JF1/MsJ ENSUMUG00000044137
 protein coding gene Chr5:130332641-130418324 (+)
LP/J ENSMUSG00230046902
 protein coding gene Chr5:131545711-131632448 (+)
NOD/ShiLtJ ENSMUSG00190040534
 protein coding gene Chr5:123345790-123441531 (+)
NZO/HlLtJ ENSMUSG00225013631
 protein coding gene Chr5:139241141-139327927 (+)
PWK/PhJ ENSLUMG00010018055
 protein coding gene Chr5:122216538-122303466 (+)
SPRET/EiJ ENSMSPG00010029879
 protein coding gene Chr5:125640853-125723184 (+)
WSB/EiJ ENSIUOG00005030003
 protein coding gene Chr5:126024472-126111207 (+)



Homology
more
  • Human Ortholog
    TYW1, tRNA-yW synthesizing protein 1 homolog
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TYW1, tRNA-yW synthesizing protein 1 homolog
  • Synonyms
    RSAFD1, TYW1A, YPL207W
  • Links
    NCBI Gene ID: 55253
    UniProt: Q9NV66

  • Chr Location
    7q11.21; chr7:66995173-67239521 (+)  GRCh38
  • Human Ortholog
    TYW1B, tRNA-yW synthesizing protein 1 homolog B
  • Synonyms
    LINC00069, NCRNA00069, RSAFD2
  • Links
    NCBI Gene ID: 441250
    UniProt: Q6NUM6

  • Chr Location
    7q11.22-q11.23; chr7:72558744-72828260 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    636
  • Tissues
    36
  • cDNA Data
    41
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056310 Ensembl Gene Model | MGI Sequence Detail 85945 C57BL/6J ±  kb
    transcript ENSMUST00000040213 Ensembl | MGI Sequence Detail 3044 Not Applicable  
    polypeptide ENSMUSP00000037173 Ensembl | MGI Sequence Detail 721 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 41

      Microarray probesets 4
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 1
      Gene Ontology 4
      Phenotypes 15
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory