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Depdc7 Gene Detail
Summary
  • Symbol
    Depdc7
  • Name
    DEP domain containing 7
  • Synonyms
    MGC:19163
  • Feature Type
    protein coding gene
  • IDs
    MGI:2139258
    NCBI Gene: 211896
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:104552129-104573202 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 54.91 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    589 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2139258
 protein coding gene Chr2:104552129-104573223 (-)
129S1/SvImJ ENSMUSG00200002340
 protein coding gene Chr2:101374418-101395742 (-)
A/J ENSMUSG00195029568
 protein coding gene Chr2:101531759-101553295 (-)
AKR/J ENSMUSG00220001578
 protein coding gene Chr2:101282813-101304353 (-)
BALB/cJ ENSMUSG00180030482
 protein coding gene Chr2:101332808-101354348 (-)
C3H/HeJ ENSMUSG00175009736
 protein coding gene Chr2:101624924-101646281 (-)
C57BL/6NJ ENSMUSG00215014165
 protein coding gene Chr2:101436985-101458082 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0024029
 protein coding gene Chr2:98195535-98216937 (-)
CAST/EiJ ENSTCUG00005001528
 protein coding gene Chr2:100704540-100725750 (-)
CBA/J ENSMUSG00210035140
 protein coding gene Chr2:101610584-101632119 (-)
DBA/2J ENSMUSG00185005547
 protein coding gene Chr2:101329567-101351104 (-)
FVB/NJ ENSMUSG00205010211
 protein coding gene Chr2:100656288-100677434 (-)
JF1/MsJ ENSUMUG00000023582
 protein coding gene Chr2:101034276-101055631 (-)
LP/J ENSMUSG00230006103
 protein coding gene Chr2:103078865-103100399 (-)
NOD/ShiLtJ ENSMUSG00190015593
 protein coding gene Chr2:101455738-101477060 (-)
NZO/HlLtJ ENSMUSG00225008156
 protein coding gene Chr2:110985528-111006624 (-)
PWK/PhJ ENSLUMG00010024119
 protein coding gene Chr2:101037475-101058853 (-)
SPRET/EiJ ENSMSPG00010033472
 protein coding gene Chr2:103079779-103100736 (-)
WSB/EiJ ENSIUOG00005001276
 protein coding gene Chr2:101135207-101156521 (-)



Homology
more
  • Human Ortholog
    DEPDC7, DEP domain containing 7
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DEPDC7, DEP domain containing 7
  • Synonyms
    dJ85M6.4, TR2
  • Links
    NCBI Gene ID: 91614
    UniProt: Q96QD5

  • Chr Location
    11p13; chr11:33015876-33033582 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    1
  • GO References
    1
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

No experimental evidence to support Cellular Component annotation, following literature review. See J:73796.
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    612
  • Tissues
    15
  • cDNA Data
    41
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 211896 NCBI Gene Model | MGI Sequence Detail 21074 C57BL/6J ±  kb
transcript NM_144804 RefSeq | MGI Sequence Detail 1780 C57BL/6  
polypeptide Q91WS7 UniProt | EBI | MGI Sequence Detail 511 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 41
    cDNA 41

    Microarray probesets 4
References
more
  • Summaries
    All 41
    Developmental Gene Expression 4
    Gene Ontology 1
    Phenotypes 13
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:391314 Mu J, et al., The mechanisms of DEPDC7-mediated actin cap establishment and meiosis progression in oocytes. EMBO Rep. 2026 Aug;27(15):4412-4432
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory