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Mael Gene Detail
Summary
  • Symbol
    Mael
  • Name
    maelstrom spermatogenic transposon silencer
  • Synonyms
    4933405K18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138453
    NCBI Gene: 98558
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:166028954-166066313 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 73.56 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    990 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2138453
 protein coding gene Chr1:166028770-166066316 (-)
129S1/SvImJ ENSMUSG00200042231
 protein coding gene Chr1:163530536-163568087 (-)
A/J ENSMUSG00195047294
 protein coding gene Chr1:162839178-162876731 (-)
AKR/J ENSMUSG00220012957
 protein coding gene Chr1:162627713-162665258 (-)
BALB/cJ ENSMUSG00180032285
 protein coding gene Chr1:163084519-163122067 (-)
C3H/HeJ ENSMUSG00175037996
 protein coding gene Chr1:163180291-163217838 (-)
C57BL/6NJ ENSMUSG00215035164
 protein coding gene Chr1:162966206-163003754 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014814
 protein coding gene Chr1:156599121-156633796 (-)
CAST/EiJ ENSTCUG00005019653
 protein coding gene Chr1:161584808-161615456 (-)
CBA/J ENSMUSG00210038849
 protein coding gene Chr1:163054746-163092292 (-)
DBA/2J ENSMUSG00185010579
 protein coding gene Chr1:167299920-167337613 (-)
FVB/NJ ENSMUSG00205009944
 protein coding gene Chr1:162098741-162136286 (-)
JF1/MsJ ENSUMUG00000004978
 protein coding gene Chr1:166451050-166488732 (-)
LP/J ENSMUSG00230019127
 protein coding gene Chr1:166919567-166957113 (-)
NOD/ShiLtJ ENSMUSG00190024386
 protein coding gene Chr1:162889625-162927167 (-)
NZO/HlLtJ ENSMUSG00225004068
 protein coding gene Chr1:170505392-170542936 (-)
PWK/PhJ ENSLUMG00010038171
 protein coding gene Chr1:161821598-161859285 (-)
SPRET/EiJ ENSMSPG00010044483
 protein coding gene Chr1:165312995-165350393 (-)
WSB/EiJ ENSIUOG00005013956
 protein coding gene Chr1:162362624-162393263 (-)



Homology
more
  • Human Ortholog
    MAEL, maelstrom spermatogenic transposon silencer
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAEL, maelstrom spermatogenic transposon silencer
  • Synonyms
    CT128, SPATA35
  • Links
    NCBI Gene ID: 84944
    UniProt: Q96JY0

  • Chr Location
    1q24.1; chr1:166975582-167022214 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Male mice homozygous for a null allele are infertile and display small testes, a complete block of spermatogenesis due to apoptosis during meiotic prophase I, defects in homologous chromosome synapsis, DNA damage, reduced DNA methylation, and derepression of L1 retrotransposons in the adult testis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    642
  • Tissues
    27
  • cDNA Data
    26
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 98558 NCBI Gene Model | MGI Sequence Detail 37360 C57BL/6J ±  kb
    transcript NM_175296 RefSeq | MGI Sequence Detail 1546 C57BL/6  
    polypeptide Q8BVN9 UniProt | EBI | MGI Sequence Detail 434 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 26
      Primer pair 3
      Antibodies 2

      Microarray probesets 3
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 18
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
    • Latest
      J:357343 De Luca C, et al., Retrotransposon LINE-1 bodies in the cytoplasm of piRNA-deficient mouse spermatocytes: Ribonucleoproteins overcoming the integrated stress response. PLoS Genet. 2023 Jun;19(6):e1010797
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory