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Tmem237 Gene Detail
Summary
  • Symbol
    Tmem237
  • Name
    transmembrane protein 237
  • Synonyms
    Als2cr4, LOC381259
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138365
    NCBI Gene: 381259
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:59139749-59159567 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 29.20 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    627 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2138365
 protein coding gene Chr1:59139743-59159567 (-)
129S1/SvImJ ENSMUSG00200018537
 protein coding gene Chr1:56640093-56659913 (-)
A/J ENSMUSG00195027419
 protein coding gene Chr1:56177837-56197661 (-)
AKR/J ENSMUSG00220039105
 protein coding gene Chr1:56268028-56287850 (-)
BALB/cJ ENSMUSG00180013870
 protein coding gene Chr1:56419502-56439287 (-)
C3H/HeJ ENSMUSG00175000966
 protein coding gene Chr1:56555293-56575113 (-)
C57BL/6NJ ENSMUSG00215022142
 protein coding gene Chr1:56487141-56506960 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014174
 protein coding gene Chr1:52821582-52838267 (-)
CAST/EiJ ENSTCUG00005012738
 protein coding gene Chr1:56330490-56349897 (-)
CBA/J ENSMUSG00210032867
 protein coding gene Chr1:56240324-56260117 (-)
DBA/2J ENSMUSG00185036690
 protein coding gene Chr1:57360041-57379834 (-)
FVB/NJ ENSMUSG00205015476
 protein coding gene Chr1:56201144-56220967 (-)
JF1/MsJ ENSUMUG00000037055
 protein coding gene Chr1:56323130-56342517 (-)
LP/J ENSMUSG00230026018
 protein coding gene Chr1:57360624-57380443 (-)
NOD/ShiLtJ ENSMUSG00190025196
 protein coding gene Chr1:56400590-56420369 (-)
NZO/HlLtJ ENSMUSG00225007651
 protein coding gene Chr1:60567488-60587305 (-)
PWK/PhJ ENSLUMG00010024006
 protein coding gene Chr1:55841236-55860714 (-)
SPRET/EiJ ENSMSPG00010023811
 protein coding gene Chr1:57784949-57802931 (-)
WSB/EiJ ENSIUOG00005020294
 protein coding gene Chr1:56025407-56044897 (-)



Homology
more
  • Human Ortholog
    TMEM237, transmembrane protein 237
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMEM237, transmembrane protein 237
  • Synonyms
    ALS2CR4, JBTS14
  • Links
    NCBI Gene ID: 65062
    UniProt: Q96Q45

  • Chr Location
    chr2:201620184-201643570 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human TMEM237 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    713
  • Tissues
    62
  • cDNA Data
    36
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038079 Ensembl Gene Model | MGI Sequence Detail 19819 C57BL/6J ±  kb
    transcript ENSMUST00000186794 Ensembl | MGI Sequence Detail 1533 Not Applicable  
    polypeptide ENSMUSP00000139823 Ensembl | MGI Sequence Detail 427 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 36

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2685818
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 12
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory