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Ifi30 Gene Detail
Summary
  • Symbol
    Ifi30
  • Name
    interferon gamma inducible protein 30
  • Synonyms
    GILT, IP30, lysosomal thio reductase IP30 precursor
Location &
Maps
more
  • Sequence Map
    Chr8:71215419-71219307 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 34.15 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    144 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2137648
 protein coding gene Chr8:71215418-71219307 (-)
129S1/SvImJ ENSMUSG00200026580
 protein coding gene Chr8:66015065-66018957 (-)
A/J ENSMUSG00195016544
 protein coding gene Chr8:66346230-66350118 (-)
AKR/J ENSMUSG00220023927
 protein coding gene Chr8:66260519-66264403 (-)
BALB/cJ ENSMUSG00180022873
 protein coding gene Chr8:65991476-65995368 (-)
C3H/HeJ ENSMUSG00175021891
 protein coding gene Chr8:66271436-66275328 (-)
C57BL/6NJ ENSMUSG00215035251
 protein coding gene Chr8:65948720-65952608 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031165
 protein coding gene Chr8:62985207-62989074 (-)
CAST/EiJ ENSTCUG00005038224
 protein coding gene Chr8:65750281-65754174 (-)
CBA/J ENSMUSG00210028343
 protein coding gene Chr8:66036977-66040869 (-)
DBA/2J ENSMUSG00185012845
 protein coding gene Chr8:72196594-72200486 (-)
FVB/NJ ENSMUSG00205040784
 protein coding gene Chr8:65541214-65545106 (-)
JF1/MsJ ENSUMUG00000037120
 protein coding gene Chr8:74474508-74478399 (-)
LP/J ENSMUSG00230034537
 protein coding gene Chr8:75808109-75812001 (-)
NOD/ShiLtJ ENSMUSG00190021396
 protein coding gene Chr8:65955826-65959714 (-)
NZO/HlLtJ ENSMUSG00225046712
 protein coding gene Chr8:79217268-79221160 (-)
PWK/PhJ ENSLUMG00010028317
 protein coding gene Chr8:65931945-65935833 (-)
SPRET/EiJ ENSMSPG00010036745
 protein coding gene Chr8:67616824-67620704 (-)
WSB/EiJ ENSIUOG00005024713
 protein coding gene Chr8:66827993-66831902 (-)



Homology
more
  • Human Ortholog
    IFI30, IFI30 lysosomal thiol reductase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IFI30, IFI30 lysosomal thiol reductase
  • Synonyms
    GILT, IFI-30, IP-30, IP30
  • Links
    NCBI Gene ID: 10437
    UniProt: P13284

  • Chr Location
    19p13.11; chr19:18173162-18178121 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
No phenotypic abormalities have been reported in mice homozygous for disruptions in this gene other than reduced efficiency in processing some antigens.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    21
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    672
  • Tissues
    10
  • cDNA Data
    6
  • Literature Summary
    1
Sequences &
Gene Models
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  • All Sequences
    38
  • RefSeq
    2
  • UniProt
    1
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031838 Ensembl Gene Model | MGI Sequence Detail 3889 C57BL/6J ±  kb
transcript ENSMUST00000222087 Ensembl | MGI Sequence Detail 980 Not Applicable  
polypeptide ENSMUSP00000159394 Ensembl | MGI Sequence Detail 248 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000008905 gamma-interferon-inducible lysosomal thiol reductase
    (term hierarchy)
  • PDB
    6NWX
  • EC
    1.8.4.-
  • InterPro Domains
    IPR004911 Gamma interferon inducible lysosomal thiol reductase GILT
  • GlyGen
    Q9ESY9 3 sites, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 7
    cDNA 7

    Microarray probesets 4
References
more
  • Summaries
    All 54
    Developmental Gene Expression 1
    Gene Ontology 9
    Phenotypes 24
  • Earliest
    J:71140 Phan UT, et al., Multiple species express thiol oxidoreductases related to GILT. Immunogenetics. 2001 May-Jun;53(4):342-6
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory