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Tm2d1 Gene Detail
Summary
  • Symbol
    Tm2d1
  • Name
    TM2 domain containing 1
  • Synonyms
    2310026L18Rik, Bbp
  • Feature Type
    protein coding gene
  • IDs
    MGI:2137022
    NCBI Gene: 94043
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:98243607-98271523 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 45.60 cM, cytoband C6
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1003 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2137022
 protein coding gene Chr4:98243607-98271543 (-)
129S1/SvImJ ENSMUSG00200026781
 protein coding gene Chr4:93220192-93248302 (-)
A/J ENSMUSG00195008273
 protein coding gene Chr4:93750165-93778106 (-)
AKR/J ENSMUSG00220005515
 protein coding gene Chr4:93228578-93256935 (-)
BALB/cJ ENSMUSG00180029452
 protein coding gene Chr4:92695583-92723522 (-)
C3H/HeJ ENSMUSG00175014229
 protein coding gene Chr4:93657846-93685786 (-)
C57BL/6NJ ENSMUSG00215009063
 protein coding gene Chr4:93617076-93645015 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026183
 protein coding gene Chr4:90479818-90506989 (-)
CAST/EiJ ENSTCUG00005007166
 protein coding gene Chr4:92947000-92973335 (-)
CBA/J ENSMUSG00210026703
 protein coding gene Chr4:93223390-93251328 (-)
DBA/2J ENSMUSG00185021162
 protein coding gene Chr4:94011812-94039920 (-)
FVB/NJ ENSMUSG00205011453
 protein coding gene Chr4:92224401-92252791 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230018604
 protein coding gene Chr4:97329776-97357882 (-)
NOD/ShiLtJ ENSMUSG00190023630
 protein coding gene Chr4:92693082-92721188 (-)
NZO/HlLtJ ENSMUSG00225002953
 protein coding gene Chr4:102472549-102500661 (-)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010007853
 protein coding gene Chr4:94081403-94106370 (-)
WSB/EiJ ENSIUOG00005002715
 protein coding gene Chr4:93021736-93049846 (-)



Homology
more
  • Human Ortholog
    TM2D1, TM2 domain containing 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TM2D1, TM2 domain containing 1
  • Synonyms
    BBP
  • Links
    NCBI Gene ID: 83941
    UniProt: Q9BX74

  • Chr Location
    1p31.3; chr1:61673636-61725423 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    46
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 94043 NCBI Gene Model | MGI Sequence Detail 27917 C57BL/6J ±  kb
transcript NM_053157 RefSeq | MGI Sequence Detail 1080 Not Specified  
polypeptide Q99MB3 UniProt | EBI | MGI Sequence Detail 208 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000016386 TM2 domain-containing protein 1
    (term hierarchy)
  • InterPro Domains
    IPR007829 TM2 domain
    IPR050932 TM2 domain-containing protein 1-3-like
  • GlyGen
    Q99MB3 5 sites, 4 N-linked glycans (4 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 46
    cDNA 46

    Microarray probesets 4
Other
Accession IDs
less
MGI:1916836, MGI:2145939
References
more
  • Summaries
    All 41
    Gene Ontology 4
    Phenotypes 17
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory