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Immp2l Gene Detail
Summary
  • Symbol
    Immp2l
  • Name
    IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)
  • Synonyms
    IMP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135611
    NCBI Gene: 93757
  • Alliance
    genome feature page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:41074089-42002371 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 18.69 cM, cytoband B3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    23871 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2135611
 protein coding gene Chr12:41074060-42002371 (+)
129S1/SvImJ ENSMUSG00200011542
 protein coding gene Chr12:32948115-33887042 (+)
A/J ENSMUSG00195017830
 protein coding gene Chr12:35629229-36567219 (+)
AKR/J ENSMUSG00220005083
 protein coding gene Chr12:33619235-34566611 (+)
BALB/cJ ENSMUSG00180003576
 protein coding gene Chr12:34616372-35554410 (+)
C3H/HeJ ENSMUSG00175016173
 protein coding gene Chr12:37669601-38607546 (+)
C57BL/6NJ ENSMUSG00215010976
 protein coding gene Chr12:34013043-34942272 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017722
 protein coding gene Chr12:37287998-38167793 (+)
CAST/EiJ ENSTCUG00005003586
 protein coding gene Chr12:34381350-35297749 (+)
CBA/J ENSMUSG00210016088
 protein coding gene Chr12:34148664-35086622 (+)
DBA/2J ENSMUSG00185019548
 protein coding gene Chr12:36169714-37100383 (+)
FVB/NJ ENSMUSG00205001253
 protein coding gene Chr12:34011308-34949701 (+)
JF1/MsJ ENSUMUG00000002391
 protein coding gene Chr12:40386145-41314132 (+)
LP/J ENSMUSG00230010202
 protein coding gene Chr12:43113229-44052084 (+)
NOD/ShiLtJ ENSMUSG00190003541
 protein coding gene Chr12:33172696-34103315 (+)
NZO/HlLtJ ENSMUSG00225030771
 protein coding gene Chr12:45332017-46270868 (+)
PWK/PhJ ENSLUMG00010012579
 protein coding gene Chr12:34521230-35437116 (+)
SPRET/EiJ ENSMSPG00010001871
 protein coding gene Chr12:35419582-36362869 (+)
WSB/EiJ ENSIUOG00005001190
 protein coding gene Chr12:33928058-34899634 (+)



Homology
more
  • Human Ortholog
    IMMP2L, inner mitochondrial membrane peptidase subunit 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IMMP2L, inner mitochondrial membrane peptidase subunit 2
  • Synonyms
    IMMP2L-IT1, IMP2, IMP2-LIKE
  • Links
    NCBI Gene ID: 83943
    UniProt: Q96T52

  • Chr Location
    7q31.1; chr7:110662644-111562517 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 3 genetic backgrounds
    11 phenotypes from multigenic genotypes
    58 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a transgenic gene disruption exhibit reduced fertility, abnormal cellular respiration, and decreased body weight.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    32
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056899 Ensembl Gene Model | MGI Sequence Detail 928283 C57BL/6J ±  kb
    transcript ENSMUST00000132121 Ensembl | MGI Sequence Detail 1147 Not Applicable  
    polypeptide ENSMUSP00000118779 Ensembl | MGI Sequence Detail 175 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 6
      cDNA 6

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2144909, MGI:2153982
    References
    more
    • Summaries
      All 92
      Diseases 1
      Gene Ontology 9
      Phenotypes 58
    • Earliest
      J:31937 Newberg MH, et al., Importance of MHC class 1 alpha2 and alpha3 domains in the recognition of self and non-self MHC molecules. J Immunol. 1996 Apr 1;156(7):2473-80
    • Latest
      J:391604 Maza PAMA, et al., Nanoplasmid PSMA DNA vaccine primes antitumor immunity and enhances response to PD-1 blockade against prostate cancer. Cancer Lett. 2026 May 22;:218591
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory