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Sez6l Gene Detail
Summary
  • Symbol
    Sez6l
  • Name
    seizure related 6 homolog like
  • Synonyms
    Acig1, mKIAA0927
  • Feature Type
    protein coding gene
  • IDs
    MGI:1935121
    NCBI Gene: 56747
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:112567017-112725051 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 54.72 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    4972 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1935121
 protein coding gene Chr5:112567017-112726401 (-)
129S1/SvImJ ENSMUSG00200021263
 protein coding gene Chr5:106308456-106466515 (-)
A/J ENSMUSG00195033349
 protein coding gene Chr5:105816972-105974913 (-)
AKR/J ENSMUSG00220051234
 protein coding gene Chr5:105327790-105485861 (-)
BALB/cJ ENSMUSG00180044385
 protein coding gene Chr5:105958765-106116888 (-)
C3H/HeJ ENSMUSG00175036360
 protein coding gene Chr5:107940183-108098110 (-)
C57BL/6NJ ENSMUSG00215030376
 protein coding gene Chr5:105965462-106123519 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027567
 protein coding gene Chr5:105346756-105510405 (-)
CAST/EiJ ENSTCUG00005021607
 protein coding gene Chr5:105141711-105301621 (-)
CBA/J ENSMUSG00210033222
 protein coding gene Chr5:106692260-106850206 (-)
DBA/2J ENSMUSG00185044198
 protein coding gene Chr5:109727437-109885507 (-)
FVB/NJ ENSMUSG00205050039
 protein coding gene Chr5:105596502-105754612 (-)
JF1/MsJ ENSUMUG00000023754
 protein coding gene Chr5:112580009-112738850 (-)
LP/J ENSMUSG00230048523
 protein coding gene Chr5:113846770-114004820 (-)
NOD/ShiLtJ ENSMUSG00190044363
 protein coding gene Chr5:105632485-105790589 (-)
NZO/HlLtJ ENSMUSG00225024412
 protein coding gene Chr5:121483177-121641288 (-)
PWK/PhJ ENSLUMG00010025101
 protein coding gene Chr5:104489873-104648931 (-)
SPRET/EiJ ENSMSPG00010040969
 protein coding gene Chr5:107751804-107905969 (-)
WSB/EiJ ENSIUOG00005039148
 protein coding gene Chr5:108333263-108491155 (-)



Homology
more
  • Human Ortholog
    SEZ6L, seizure related 6 homolog like
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SEZ6L, seizure related 6 homolog like
  • Synonyms
    SEZ6L1
  • Links
    NCBI Gene ID: 23544
    UniProt: Q9BYH1

  • Chr Location
    22q12.1; chr22:26169462-26383597 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display slightly impaired coordination in the rotarod task.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    5
Molecular Function

No experimental evidence to support Molecular Function annotation, following literature review. See J:73796.
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    665
  • Tissues
    33
  • cDNA Data
    80
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000058153 Ensembl Gene Model | MGI Sequence Detail 158035 C57BL/6J ±  kb
    transcript ENSMUST00000212480 Ensembl | MGI Sequence Detail 5857 Not Applicable  
    polypeptide ENSMUSP00000148791 Ensembl | MGI Sequence Detail 964 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 80
      cDNA 80

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2140978, MGI:2141215
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 8
      Gene Ontology 5
      Phenotypes 22
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:359963 de Haan S, et al., Jag1 represses Notch activation in lateral supporting cells and inhibits an outer hair cell fate in the medial cochlea. Development. 2024 Nov 1;151(21)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory