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Defb5 Gene Detail
Summary
  • Symbol
    Defb5
  • Name
    defensin beta 5
Location &
Maps
more
  • Sequence Map
    Chr8:19297596-19300844 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 10.35 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    387 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933153
 protein coding gene Chr8:19297588-19300957 (+)
129S1/SvImJ ENSMUSG00200029174
 protein coding gene Chr8:16103325-16106572 (+)
A/J ENSMUSG00195038459
 protein coding gene Chr8:16526406-16529653 (+)
AKR/J ENSMUSG00220030689
 protein coding gene Chr8:16295670-16298918 (+)
BALB/cJ ENSMUSG00180020797
 protein coding gene Chr8:16146754-16150001 (+)
C3H/HeJ ENSMUSG00175036822
 protein coding gene Chr8:16324813-16328060 (+)
C57BL/6NJ ENSMUSG00215023730
 protein coding gene Chr8:16267715-16270963 (+)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005018023
 protein coding gene Chr8:16103383-16105160 (+)
CBA/J ENSMUSG00210041581
 protein coding gene Chr8:16163645-16166892 (+)
DBA/2J ENSMUSG00185006544
 protein coding gene Chr8:16291451-16294698 (+)
FVB/NJ ENSMUSG00205023624
 protein coding gene Chr8:16172936-16176183 (+)
JF1/MsJ ENSUMUG00000031263
 protein coding gene Chr8:16200610-16203889 (+)
LP/J ENSMUSG00230019136
 protein coding gene Chr8:18376217-18379466 (+)
NOD/ShiLtJ ENSMUSG00190028902
 protein coding gene Chr8:16295897-16299144 (+)
NZO/HlLtJ ENSMUSG00225041623
 protein coding gene Chr8:26231124-26234372 (+)
PWK/PhJ ENSLUMG00010026061
 protein coding gene Chr8:16170656-16173910 (+)
SPRET/EiJ ENSMSPG00010013146
 protein coding gene Chr8:16408160-16411402 (+)
WSB/EiJ ENSIUOG00005018485
 protein coding gene Chr8:16237540-16240788 (+)



Homology
more
  • Human Ortholog
    DEFB4A, defensin beta 4A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DEFB4A, defensin beta 4A
  • Synonyms
    BD-2, DEFB102, DEFB-2, DEFB2, DEFB4, HBD-2, SAP1
  • Links
    NCBI Gene ID: 1673
    UniProt: O15263

  • Chr Location
    8p23.1
  • Human Ortholog
    DEFB4B, defensin beta 4B
  • Synonyms
    DEFB4P
  • Links
    NCBI Gene ID: 100289462

  • Chr Location
    8
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039785 Ensembl Gene Model | MGI Sequence Detail 3249 C57BL/6J ±  kb
transcript ENSMUST00000110763 Ensembl | MGI Sequence Detail 207 Not Applicable  
polypeptide ENSMUSP00000106391 Ensembl | MGI Sequence Detail 64 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less

  • Microarray probesets 2
References
more
  • Summaries
    All 23
    Gene Ontology 6
    Phenotypes 4
  • Earliest
    J:78153 Morrison GM, et al., Identification and characterization of a novel murine beta-defensin-related gene. Mamm Genome. 2002 Aug;13(8):445-51
  • Latest
    J:332494 Dong X, et al., Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection. Immunity. 2022 Jul 15;55(9):1645-1662
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory