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Cblc Gene Detail
Summary
  • Symbol
    Cblc
  • Name
    Cbl proto-oncogene c
  • Synonyms
    2310076I21Rik, 2310079L19Rik, Cbl3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1931457
    NCBI Gene: 80794
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:19513643-19530734 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 9.94 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    591 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1931457
 protein coding gene Chr7:19512806-19530734 (-)
129S1/SvImJ ENSMUSG00200038229
 protein coding gene Chr7:12710568-12728634 (-)
A/J ENSMUSG00195050439
 protein coding gene Chr7:13150492-13168252 (-)
AKR/J ENSMUSG00220025911
 protein coding gene Chr7:11482385-11500255 (-)
BALB/cJ ENSMUSG00180053139
 protein coding gene Chr7:13006818-13024572 (-)
C3H/HeJ ENSMUSG00175040660
 protein coding gene Chr7:13593107-13611198 (-)
C57BL/6NJ ENSMUSG00215054712
 protein coding gene Chr7:10679442-10697199 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0029309
 protein coding gene Chr7:19077761-19095100 (-)
CAST/EiJ ENSTCUG00005049857
 protein coding gene Chr7:13614990-13632369 (-)
CBA/J ENSMUSG00210051216
 protein coding gene Chr7:12819644-12837704 (-)
DBA/2J ENSMUSG00185050837
 protein coding gene Chr7:16263587-16281505 (-)
FVB/NJ ENSMUSG00205050054
 protein coding gene Chr7:13201661-13219524 (-)
JF1/MsJ ENSUMUG00000024518
 protein coding gene Chr7:19577083-19595160 (-)
LP/J ENSMUSG00230052578
 protein coding gene Chr7:20552268-20570341 (-)
NOD/ShiLtJ ENSMUSG00190037792
 protein coding gene Chr7:9475964-9494030 (-)
NZO/HlLtJ ENSMUSG00225052242
 protein coding gene Chr7:17845371-17863228 (-)
PWK/PhJ ENSLUMG00010043325
 protein coding gene Chr7:2433908-2451974 (-)
SPRET/EiJ ENSMSPG00010043080
 protein coding gene Chr7:12553801-12569708 (-)
WSB/EiJ ENSIUOG00005052616
 protein coding gene Chr7:19043570-19061424 (+)



Homology
more
  • Human Ortholog
    CBLC, Cbl proto-oncogene C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CBLC, Cbl proto-oncogene C
  • Synonyms
    CBL-3, CBL-SL, RNF57
  • Links
    NCBI Gene ID: 23624
    UniProt: Q9ULV8

  • Chr Location
    19q13.32; chr19:44777845-44802291 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    7 phenotype references
Homozygous null mice are viable, fertile, and show no abnormalities of the epithelium or other tissues.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    791
  • Tissues
    57
  • cDNA Data
    33
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 80794 NCBI Gene Model | MGI Sequence Detail 17092 C57BL/6J ±  kb
transcript NM_023224 RefSeq | MGI Sequence Detail 1677 C57BL/6  
polypeptide Q80XL1 UniProt | EBI | MGI Sequence Detail 496 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 36
    cDNA 35
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGI:1913812, MGI:1919198
References
more
  • Summaries
    All 45
    Developmental Gene Expression 5
    Gene Ontology 8
    Phenotypes 7
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:279933 Zhang X, et al., Loss-of-function mutations in FREM2 disrupt eye morphogenesis. Exp Eye Res. 2019 Apr;181:302-312
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory