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Tnmd Gene Detail
Summary
  • Symbol
    Tnmd
  • Name
    tenomodulin
  • Synonyms
    1110017I01Rik, Bricd4, ChM1L, myodulin, TeM, tendin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929885
    NCBI Gene: 64103
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:132751757-132766326 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 55.47 cM, cytoband E3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    345 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929885
 protein coding gene ChrX:132751729-132766326 (+)
129S1/SvImJ ENSMUSG00200011296
 protein coding gene ChrX:111801121-111815723 (+)
A/J ENSMUSG00195043946
 protein coding gene ChrX:115669822-115684428 (+)
AKR/J ENSMUSG00220012590
 protein coding gene ChrX:109278730-109293334 (+)
BALB/cJ ENSMUSG00180018705
 protein coding gene ChrX:112087995-112102596 (+)
C3H/HeJ ENSMUSG00175030388
 protein coding gene ChrX:115936393-115950995 (+)
C57BL/6NJ ENSMUSG00215002705
 protein coding gene ChrX:112457603-112472199 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033379
 protein coding gene ChrX:122634491-122652501 (+)
CAST/EiJ ENSTCUG00005036217
 protein coding gene ChrX:113264400-113278984 (+)
CBA/J ENSMUSG00210038851
 protein coding gene ChrX:112838019-112852621 (+)
DBA/2J ENSMUSG00185029731
 protein coding gene ChrX:126762445-126777050 (+)
FVB/NJ ENSMUSG00205010944
 protein coding gene ChrX:111466053-111480658 (+)
JF1/MsJ ENSUMUG00000014708
 protein coding gene ChrX:145926263-145940825 (+)
LP/J ENSMUSG00230038127
 protein coding gene ChrX:133451187-133465789 (+)
NOD/ShiLtJ ENSMUSG00190031569
 protein coding gene ChrX:112273879-112288478 (+)
NZO/HlLtJ ENSMUSG00225036333
 protein coding gene ChrX:138111678-138126277 (+)
PWK/PhJ ENSLUMG00010009146
 protein coding gene ChrX:110594861-110609458 (+)
SPRET/EiJ ENSMSPG00010032048
 protein coding gene ChrX:115435058-115450253 (+)
WSB/EiJ ENSIUOG00005034145
 protein coding gene ChrX:113018145-113032747 (+)



Homology
more
  • Human Ortholog
    TNMD, tenomodulin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNMD, tenomodulin
  • Synonyms
    BRICD4, CHM1L, TEM
  • Links
    NCBI Gene ID: 64102
    UniProt: Q9H2S6

  • Chr Location
    Xq22.1; chrX:100584936-100599885 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous females exhibit a decrease in tenocyte proliferation and tendons have a greater variation of collagen fibril calibers exhibiting increased maximal diameters.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    932
  • Tissues
    157
  • cDNA Data
    41
  • Literature Summary
    51
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 64103 NCBI Gene Model | MGI Sequence Detail 14570 C57BL/6J ±  kb
    transcript NM_022322 RefSeq | MGI Sequence Detail 1338 C57BL/6  
    polypeptide Q9EP64 UniProt | EBI | MGI Sequence Detail 317 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      cDNA 41
      Primer pair 7
      Other 3
      Antibodies 4

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1913410
    References
    more
    • Summaries
      All 89
      Developmental Gene Expression 51
      Gene Ontology 3
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:387191 Yambe S, et al., Divergent temporal control of deltoid tuberosity and limb tendon development by an evolutionarily conserved scleraxis enhancer. Development. 2026 May 15;153(10):dev205325
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory