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Bin3 Gene Detail
Summary
  • Symbol
    Bin3
  • Name
    bridging integrator 3
  • Synonyms
    1700015F07Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929883
    NCBI Gene: 57784
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:70337538-70375413 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 36.21 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    729 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929883
 protein coding gene Chr14:70337538-70375655 (+)
129S1/SvImJ ENSMUSG00200027040
 protein coding gene Chr14:58729687-58766699 (+)
A/J ENSMUSG00195013305
 protein coding gene Chr14:58910565-58948669 (+)
AKR/J ENSMUSG00220030094
 protein coding gene Chr14:58246311-58284413 (+)
BALB/cJ ENSMUSG00180035004
 protein coding gene Chr14:58519131-58557232 (+)
C3H/HeJ ENSMUSG00175032661
 protein coding gene Chr14:60279633-60317732 (+)
C57BL/6NJ ENSMUSG00215012721
 protein coding gene Chr14:58455796-58493903 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019473
 protein coding gene Chr14:61199869-61238779 (+)
CAST/EiJ ENSTCUG00005036730
 protein coding gene Chr14:60159046-60197983 (+)
CBA/J ENSMUSG00210032577
 protein coding gene Chr14:58895486-58933585 (+)
DBA/2J ENSMUSG00185023501
 protein coding gene Chr14:64065045-64103141 (+)
FVB/NJ ENSMUSG00205021115
 protein coding gene Chr14:58405734-58443834 (+)
JF1/MsJ ENSUMUG00000027860
 protein coding gene Chr14:75240529-75277541 (+)
LP/J ENSMUSG00230013668
 protein coding gene Chr14:76093447-76130459 (+)
NOD/ShiLtJ ENSMUSG00190033481
 protein coding gene Chr14:58690634-58728731 (+)
NZO/HlLtJ ENSMUSG00225038677
 protein coding gene Chr14:66417480-66455578 (+)
PWK/PhJ ENSLUMG00010037743
 protein coding gene Chr14:58090274-58128205 (+)
SPRET/EiJ ENSMSPG00010026017
 protein coding gene Chr14:61654983-61705007 (+)
WSB/EiJ ENSIUOG00005036836
 protein coding gene Chr14:58136103-58173965 (+)



Homology
more
  • Human Ortholog
    BIN3, bridging integrator 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BIN3, bridging integrator 3
  • Links
    NCBI Gene ID: 55909
    UniProt: Q9NQY0

  • Chr Location
    8p21.3; chr8:22620418-22669148 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice develop juvenile cataracts characterized by defects in cytoskeletal filamentous actin organization, show a higher incidence of spontaneous lymphomas during aging, and display a greater sensitivity to lung adenocarcinoma formation in response to radiation or carcinogen treatment.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    623
  • Tissues
    10
  • cDNA Data
    55
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 57784 NCBI Gene Model | MGI Sequence Detail 37876 C57BL/6J ±  kb
    transcript NM_021328 RefSeq | MGI Sequence Detail 1559 C57BL/6  
    polypeptide Q9JI08 UniProt | EBI | MGI Sequence Detail 253 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 58
      cDNA 55
      Primer pair 2
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGI:1916644
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 3
      Gene Ontology 8
      Phenotypes 9
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:307860 Choquet H, et al., A large multiethnic GWAS meta-analysis of cataract identifies new risk loci and sex-specific effects. Nat Commun. 2021 Jun 14;12(1):3595
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory