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Lrp10 Gene Detail
Summary
  • Symbol
    Lrp10
  • Name
    low-density lipoprotein receptor-related protein 10
  • Synonyms
    Lrp9
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929480
    NCBI Gene: 65107
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:54701260-54707749 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 27.80 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    211 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929480
 protein coding gene Chr14:54701260-54708954 (+)
129S1/SvImJ ENSMUSG00200039430
 protein coding gene Chr14:43282380-43282465 (+)
A/J ENSMUSG00195032953
 protein coding gene Chr14:43506667-43506752 (+)
AKR/J ENSMUSG00220026711
 protein coding gene Chr14:42834635-42834720 (+)
BALB/cJ ENSMUSG00180050875
 protein coding gene Chr14:43130427-43130512 (+)
C3H/HeJ ENSMUSG00175046262
 protein coding gene Chr14:44812860-44812945 (+)
C57BL/6NJ ENSMUSG00215047724
 protein coding gene Chr14:43025490-43025575 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019256
 protein coding gene Chr14:45894324-45901559 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210041812
 protein coding gene Chr14:43493392-43493477 (+)
DBA/2J ENSMUSG00185052510
 protein coding gene Chr14:48540258-48540343 (+)
FVB/NJ ENSMUSG00205022017
 protein coding gene Chr14:42882479-42882564 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230052216
 protein coding gene Chr14:60648337-60648422 (+)
NOD/ShiLtJ ENSMUSG00190030275
 protein coding gene Chr14:43243405-43243490 (+)
NZO/HlLtJ ENSMUSG00225049952
 protein coding gene Chr14:50946441-50946526 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    LRP10, LDL receptor related protein 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LRP10, LDL receptor related protein 10
  • Synonyms
    LRP-10, LRP9, MST087, MSTP087
  • Links
    NCBI Gene ID: 26020
    UniProt: Q7Z4F1

  • Chr Location
    14q11.2; chr14:22871709-22881713 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    699
  • Tissues
    67
  • cDNA Data
    136
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 65107 NCBI Gene Model | MGI Sequence Detail 6490 C57BL/6J ±  kb
transcript NM_022993 RefSeq | MGI Sequence Detail 3013 C57BL/6  
polypeptide Q7TQH7 UniProt | EBI | MGI Sequence Detail 713 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 141
    cDNA 140
    Primer pair 1
    Antibodies 1

    Microarray probesets 2
References
more
  • Summaries
    All 39
    Developmental Gene Expression 7
    Gene Ontology 5
    Phenotypes 10
  • Earliest
    J:36742 Pons S, et al., The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase. Mol Cell Biol. 1995 Aug;15(8):4453-65
  • Latest
    J:363549 Russell J, et al., Lrp10 suppresses IL7R limiting CD8 T cell homeostatic expansion and anti-tumor immunity. EMBO Rep. 2024 Aug;25(8):3601-3626
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory