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Irak1bp1 Gene Detail
Summary
  • Symbol
    Irak1bp1
  • Name
    interleukin-1 receptor-associated kinase 1 binding protein 1
  • Synonyms
    4921528N06Rik, AIP70, SIMPL
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929475
    NCBI Gene: 65099
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:82711859-82729741 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 45.16 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    600 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929475
 protein coding gene Chr9:82711593-82729741 (+)
129S1/SvImJ ENSMUSG00200018695
 protein coding gene Chr9:79793659-79811798 (+)
A/J ENSMUSG00195009924
 protein coding gene Chr9:79608836-79626975 (+)
AKR/J ENSMUSG00220014566
 protein coding gene Chr9:79705057-79723232 (+)
BALB/cJ ENSMUSG00180015996
 protein coding gene Chr9:79716399-79734538 (+)
C3H/HeJ ENSMUSG00175010595
 protein coding gene Chr9:79776431-79794568 (+)
C57BL/6NJ ENSMUSG00215007000
 protein coding gene Chr9:79716429-79734578 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032483
 protein coding gene Chr9:79535247-79554592 (+)
CAST/EiJ ENSTCUG00005008922
 protein coding gene Chr9:79333445-79353175 (+)
CBA/J ENSMUSG00210013046
 protein coding gene Chr9:79811705-79829880 (+)
DBA/2J ENSMUSG00185007068
 protein coding gene Chr9:79834284-79852421 (+)
FVB/NJ ENSMUSG00205017082
 protein coding gene Chr9:80009437-80027576 (+)
JF1/MsJ ENSUMUG00000018869
 protein coding gene Chr9:79712396-79730572 (+)
LP/J ENSMUSG00230021297
 protein coding gene Chr9:79931917-79950056 (+)
NOD/ShiLtJ ENSMUSG00190031344
 protein coding gene Chr9:79906468-79924643 (+)
NZO/HlLtJ ENSMUSG00225024578
 protein coding gene Chr9:80132070-80150207 (+)
PWK/PhJ ENSLUMG00010015167
 protein coding gene Chr9:79649062-79667242 (+)
SPRET/EiJ ENSMSPG00010003923
 protein coding gene Chr9:80988548-81005983 (+)
WSB/EiJ ENSIUOG00005023733
 protein coding gene Chr9:79298571-79316708 (+)



Homology
more
  • Human Ortholog
    IRAK1BP1, interleukin 1 receptor associated kinase 1 binding protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IRAK1BP1, interleukin 1 receptor associated kinase 1 binding protein 1
  • Synonyms
    AIP70, SIMPL
  • Links
    NCBI Gene ID: 134728
    UniProt: Q5VVH5

  • Chr Location
    6q14.1; chr6:78867551-78979411 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    609
  • Tissues
    12
  • cDNA Data
    29
  • Literature Summary
    1
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 65099 NCBI Gene Model | MGI Sequence Detail 17883 C57BL/6J ±  kb
transcript NM_022986 RefSeq | MGI Sequence Detail 1893 C57BL/6  
polypeptide Q9ESJ7 UniProt | EBI | MGI Sequence Detail 259 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000009101 interleukin-1 receptor-associated kinase 1-binding protein 1
    (term hierarchy)
  • InterPro Domains
    IPR030312 Interleukin-1 receptor-associated kinase 1-binding protein 1
    IPR007497 Interleukin-1 receptor-associated kinase 1-binding protein 1/DUF541
Molecular
Reagents
less
  • All nucleic 29
    cDNA 29

    Microarray probesets 4
Other
Accession IDs
less
MGI:1913981, MGI:2143152
References
more
  • Summaries
    All 36
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 10
  • Earliest
    J:66320 Pfeuffer T, et al., LaXp180, a mammalian ActA-binding protein, identified with the yeast two-hybrid system, co-localizes with intracellular Listeria monocytogenes. Cell Microbiol. 2000 Apr;2(2):101-14
  • Latest
    J:200629 Zhao W, et al., SIMPL enhancement of tumor necrosis factor-alpha dependent p65-MED1 complex formation is required for mammalian hematopoietic stem and progenitor cell function. PLoS One. 2013;8(4):e61123
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory