B4galt3 MGI Mouse Gene Detail - MGI:1928767 - UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3

Symbol

B4galt3
Name

UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3
Synonyms

9530061M23Rik, beta4GalT-III, ESTM26, R74981

Feature Type

protein coding gene
IDs

MGI:1928767
NCBI Gene: 57370
Alliance

genome feature page
Transcription Start Sites

3 TSS

Sequence Map

Chr1:171097898-171104468 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 79.29 cM
Mapping Data

5 experiments

SNPs within 2kb

201 from dbSNP Build 142
Strain Annotations

27
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1928767	protein coding gene	Chr1:171097898-171104469 (+)
129S1/SvImJ	ENSMUSGG00200054517	protein coding gene	Chr1:168587341-168590255 (+)
129S1/SvImJ	ENSMUSG00200046293	protein coding gene	Chr1:168585026-168585990 (+)
A/J	ENSMUSGG00195055122	protein coding gene	Chr1:167940682-167943596 (+)
A/J	ENSMUSG00195048087	protein coding gene	Chr1:167938367-167939331 (+)
AKR/J	ENSMUSG00220026358	protein coding gene	Chr1:167683143-167684107 (+)
AKR/J	ENSMUSGG00220054436	protein coding gene	Chr1:167685456-167688401 (+)
BALB/cJ	ENSMUSG00180044079	protein coding gene	Chr1:168225284-168226248 (+)
BALB/cJ	ENSMUSGG00180055051	protein coding gene	Chr1:168227599-168230513 (+)
C3H/HeJ	ENSMUSGG00175054753	protein coding gene	Chr1:168238692-168241606 (+)
C3H/HeJ	ENSMUSG00175040751	protein coding gene	Chr1:168236377-168237341 (+)
C57BL/6NJ	ENSMUSGG00215055738	protein coding gene	Chr1:168058323-168061268 (+)
C57BL/6NJ	ENSMUSG00215044082	protein coding gene	Chr1:168056010-168056974 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014861	protein coding gene	Chr1:161531800-161538921 (+)
CAST/EiJ	no annotation
CBA/J	ENSMUSG00210033915	protein coding gene	Chr1:168113306-168114270 (+)
CBA/J	ENSMUSGG00210054718	protein coding gene	Chr1:168115621-168118535 (+)
DBA/2J	ENSMUSGG00185057458	protein coding gene	Chr1:172429571-172432485 (+)
DBA/2J	ENSMUSG00185027345	protein coding gene	Chr1:172427256-172428220 (+)
FVB/NJ	ENSMUSG00205033620	protein coding gene	Chr1:167122399-167123363 (+)
FVB/NJ	ENSMUSGG00205054106	protein coding gene	Chr1:167124714-167127628 (+)
JF1/MsJ	no annotation
LP/J	ENSMUSG00230024965	protein coding gene	Chr1:172002148-172003112 (+)
LP/J	ENSMUSGG00230055839	protein coding gene	Chr1:172004463-172007377 (+)
NOD/ShiLtJ	ENSMUSGG00190054603	protein coding gene	Chr1:167910120-167913041 (+)
NOD/ShiLtJ	ENSMUSG00190031487	protein coding gene	Chr1:167907808-167908772 (+)
NZO/HlLtJ	ENSMUSG00225003816	protein coding gene	Chr1:175621921-175622885 (+)
NZO/HlLtJ	ENSMUSGG00225055298	protein coding gene	Chr1:175624236-175627150 (+)
PWK/PhJ	no annotation
SPRET/EiJ	ENSMSPG00010045104	protein coding gene	Chr1:170435445-170441151 (+)
WSB/EiJ	no annotation

Human Ortholog

B4GALT3, beta-1,4-galactosyltransferase 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

B4GALT3, beta-1,4-galactosyltransferase 3
Synonyms

beta4Gal-T3
Links

HGNC:926

NCBI Gene ID: 8703

UniProt: O60512
Chr Location

1q23.3; chr1:161171306-161178652 (-) GRCh38

MGI Vertebrate Homology

B4galt3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: B4GALT3
Gene Tree

B4galt3

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

2
Endonuclease-mediated

4
Gene trapped

1
Targeted

2
Genomic Mutations

2 involving B4galt3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

42 strains or lines available

Homozygous null mice show suppression of growth of strongly immunogenic tumors.

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All GO Annotations

23
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

700
Tissues

103
cDNA Data

11
Literature Summary

2

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

73
RefSeq

4
UniProt

6
CCDS

CCDS15486.1

Ensembl

ENSMUSG00000052423 (Evidence)
NCBI Gene

57370

			Length	Strain/Species	Flank
genomic	57370	NCBI Gene Model \| MGI Sequence Detail	6571	C57BL/6J	± kb
transcript	NM_020579	RefSeq \| MGI Sequence Detail	1991	C57BL/6
polypeptide	Q91YY2	UniProt \| EBI \| MGI Sequence Detail	395	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000004607 beta-1,4-galactosyltransferase 3

(term hierarchy)
EC

2.4.1.-, 2.4.1.275, 2.4.1.38, 2.4.1.90
InterPro Domains

IPR003859 Beta-1,4-galactosyltransferase

IPR027791 Galactosyltransferase, C-terminal

IPR027995 Galactosyltransferase, N-terminal

IPR029044 Nucleotide-diphospho-sugar transferases
GlyGen

Q91YY2 4 sites, 6 N-linked glycans (4 sites)

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All nucleic 15

Genomic 2

cDNA 12

Primer pair 1

Microarray probesets 3

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MGD-MRK-28118, MGI:104824, MGI:1334438, MGI:1915539, MGI:2138567, MGI:2138730

Summaries

All 47

Developmental Gene Expression 2

Gene Ontology 8

Phenotypes 10
Earliest

J:28401 Bettenhausen B, et al., Efficient isolation of novel mouse genes differentially expressed in early postimplantation embryos. Genomics. 1995 Aug 10;28(3):436-41
Latest

J:343168 Wei H, et al., Beta-1,4-galactosyltransferase-3 deficiency suppresses the growth of immunogenic tumors in mice. Front Immunol. 2023;14:1272537

TSS for B4galt3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10004	Chr1:171097891-171097930 (+)	13 bp
Tssr10005	Chr1:171097945-171097956 (+)	53 bp
Tssr10006	Chr1:171099197-171099199 (+)	1,300 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/15/2026 MGI 6.29