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Get3 Gene Detail
Summary
  • Symbol
    Get3
  • Name
    guided entry of tail-anchored proteins factor 3, ATPase
  • Synonyms
    1810048H22Rik, ArsA, Asna1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1928379
    NCBI Gene: 56495
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:85744560-85751910 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 41.48 cM, cytoband C3-D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    240 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1928379
 protein coding gene Chr8:85744558-85751916 (-)
129S1/SvImJ ENSMUSG00200024364
 protein coding gene Chr8:80109726-80116898 (-)
A/J ENSMUSG00195014910
 protein coding gene Chr8:80467768-80474953 (-)
AKR/J ENSMUSG00220022769
 protein coding gene Chr8:80509325-80516498 (-)
BALB/cJ ENSMUSG00180019870
 protein coding gene Chr8:80308436-80315611 (-)
C3H/HeJ ENSMUSG00175010888
 protein coding gene Chr8:80403454-80410639 (-)
C57BL/6NJ ENSMUSG00215009965
 protein coding gene Chr8:80040886-80048236 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031324
 protein coding gene Chr8:76367844-76375435 (-)
CAST/EiJ ENSTCUG00005036134
 protein coding gene Chr8:79917727-79924979 (-)
CBA/J ENSMUSG00210030562
 protein coding gene Chr8:80390567-80397752 (-)
DBA/2J ENSMUSG00185037196
 protein coding gene Chr8:86499159-86506344 (-)
FVB/NJ ENSMUSG00205033836
 protein coding gene Chr8:79446419-79453604 (-)
JF1/MsJ ENSUMUG00000013252
 protein coding gene Chr8:88807556-88814906 (-)
LP/J ENSMUSG00230024267
 protein coding gene Chr8:90106705-90113878 (-)
NOD/ShiLtJ ENSMUSG00190015099
 protein coding gene Chr8:80466876-80474061 (-)
NZO/HlLtJ ENSMUSG00225040052
 protein coding gene Chr8:93501574-93508923 (-)
PWK/PhJ ENSLUMG00010028125
 protein coding gene Chr8:80144611-80151973 (-)
SPRET/EiJ ENSMSPG00010025049
 protein coding gene Chr8:82057500-82064736 (-)
WSB/EiJ ENSIUOG00005018266
 protein coding gene Chr8:81204649-81211822 (-)



Homology
more
  • Human Ortholog
    GET3, guided entry of tail-anchored proteins factor 3, ATPase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GET3, guided entry of tail-anchored proteins factor 3, ATPase
  • Synonyms
    ARSA1, ARSA-I, ASNA1, ASNA-I, CMD2H, TRC40
  • Links
    NCBI Gene ID: 439
    UniProt: O43681

  • Chr Location
    19p13.13; chr19:12737106-12748325 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GET3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display early embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    750
  • Tissues
    33
  • cDNA Data
    69
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000052456 Ensembl Gene Model | MGI Sequence Detail 7351 C57BL/6J ±  kb
transcript ENSMUST00000064314 Ensembl | MGI Sequence Detail 1256 Not Applicable  
polypeptide ENSMUSP00000065337 Ensembl | MGI Sequence Detail 348 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 71
    Genomic 1
    cDNA 69
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1917094, MGI:6393843
References
more
  • Summaries
    All 80
    Developmental Gene Expression 4
    Gene Ontology 11
    Phenotypes 42
  • Earliest
    J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
  • Latest
    J:376296 Feng W, et al., ASNA1 is essential for cardiac development and function by regulating tail-anchored protein stability and vesicular transport in cardiomyocytes. PLoS Genet. 2025 Dec;21(12):e1011964
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory