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Gipc1 Gene Detail
Summary
  • Symbol
    Gipc1
  • Name
    GIPC PDZ domain containing family, member 1
  • Synonyms
    Glut1CIP, neurophilin1-IP, Rgs19ip1, Semcap1, synectin, TaxIP2, TIP-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926252
    NCBI Gene: 67903
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:84379306-84391323 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 40.22 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    317 from dbSNP Build 142
  • Strain Annotations
    26
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1926252
 protein coding gene Chr8:84376037-84391418 (+)
129S1/SvImJ ENSMUSG00200023325
 protein coding gene Chr8:78758905-78759133 (+)
129S1/SvImJ ENSMUSGG00200054657
 protein coding gene Chr8:78759901-78760312 (+)
A/J ENSMUSG00195015563
 protein coding gene Chr8:79116525-79116753 (+)
A/J ENSMUSGG00195054900
 protein coding gene Chr8:79117521-79117932 (+)
AKR/J ENSMUSG00220022996
 protein coding gene Chr8:79156342-79156570 (+)
AKR/J ENSMUSGG00220054883
 protein coding gene Chr8:79157338-79157749 (+)
BALB/cJ ENSMUSGG00180055238
 protein coding gene Chr8:78958572-78958983 (+)
BALB/cJ ENSMUSG00180017337
 protein coding gene Chr8:78957576-78957804 (+)
C3H/HeJ ENSMUSG00175010244
 protein coding gene Chr8:79047412-79047640 (+)
C3H/HeJ ENSMUSGG00175055025
 protein coding gene Chr8:79048408-79048819 (+)
C57BL/6NJ ENSMUSG00215017510
 protein coding gene Chr8:78682056-78682284 (+)
C57BL/6NJ ENSMUSGG00215055405
 protein coding gene Chr8:78683052-78683463 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031274
 protein coding gene Chr8:74974706-74987040 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210020162
 protein coding gene Chr8:79039719-79039947 (+)
CBA/J ENSMUSGG00210055016
 protein coding gene Chr8:79040715-79041126 (+)
DBA/2J ENSMUSGG00185057599
 protein coding gene Chr8:85149525-85149936 (+)
DBA/2J ENSMUSG00185033474
 protein coding gene Chr8:85148529-85148757 (+)
FVB/NJ ENSMUSG00205017546
 protein coding gene Chr8:78093562-78093790 (+)
FVB/NJ ENSMUSGG00205054244
 protein coding gene Chr8:78094558-78094969 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230024907
 protein coding gene Chr8:88755763-88755991 (+)
LP/J ENSMUSGG00230055439
 protein coding gene Chr8:88756759-88757170 (+)
NOD/ShiLtJ ENSMUSG00190022438
 protein coding gene Chr8:79105821-79106049 (+)
NOD/ShiLtJ ENSMUSGG00190054790
 protein coding gene Chr8:79106817-79107228 (+)
NZO/HlLtJ ENSMUSGG00225055169
 protein coding gene Chr8:92144217-92144628 (+)
NZO/HlLtJ ENSMUSG00225038750
 protein coding gene Chr8:92143221-92143449 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    GIPC1, GIPC PDZ domain containing family member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GIPC1, GIPC PDZ domain containing family member 1
  • Synonyms
    C19orf3, GIPC, GLUT1CBP, Hs.6454, IIP-1, NIP, OPDM2, RGS19IP1, SEMCAP, SYNECTIIN, SYNECTIN, TIP-2
  • Links
    NCBI Gene ID: 10755
    UniProt: O14908

  • Chr Location
    19p13.12; chr19:14477759-14496157 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GIPC1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 3 alleles in 5 genetic backgrounds
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele display reduced body and heart weight, selective arteriogenesis and arterial endothelial cell defects, and impaired cardiac performance and wound healing. Mice homozygous for a knock-out allele exhibit low molecular weight proteinuria.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    65
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    689
  • Tissues
    72
  • cDNA Data
    62
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019433 Ensembl Gene Model | MGI Sequence Detail 12018 C57BL/6J ±  kb
    transcript ENSMUST00000019577 Ensembl | MGI Sequence Detail 1522 Not Applicable  
    polypeptide ENSMUSP00000019577 Ensembl | MGI Sequence Detail 333 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 65
      cDNA 63
      Other 2
      Antibodies 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1861792
    References
    more
    • Summaries
      All 107
      Developmental Gene Expression 6
      Gene Ontology 17
      Phenotypes 54
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:348117 Okuma H, et al., N-terminal domain on dystroglycan enables LARGE1 to extend matriglycan on alpha-dystroglycan and prevents muscular dystrophy. Elife. 2023 Feb 1;12
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory