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Vps33a Gene Detail
Summary
  • Symbol
    Vps33a
  • Name
    VPS33A CORVET/HOPS core subunit
  • Synonyms
    3830421M04Rik, bf
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924823
    NCBI Gene: 77573
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:123666820-123711104 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 63.03 cM
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    946 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924823
 protein coding gene Chr5:123666722-123711104 (-)
129S1/SvImJ ENSMUSG00200023782
 protein coding gene Chr5:117386259-117426969 (-)
A/J ENSMUSG00195011727
 protein coding gene Chr5:116907704-116948413 (-)
AKR/J ENSMUSG00220035384
 protein coding gene Chr5:116422464-116452695 (-)
BALB/cJ ENSMUSG00180031152
 protein coding gene Chr5:117022659-117063368 (-)
C3H/HeJ ENSMUSG00175028913
 protein coding gene Chr5:119042283-119072507 (-)
C57BL/6NJ ENSMUSG00215024982
 protein coding gene Chr5:117075107-117119492 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027730
 protein coding gene Chr5:116539681-116565122 (-)
CAST/EiJ ENSTCUG00005036063
 protein coding gene Chr5:116330605-116359411 (-)
CBA/J ENSMUSG00210009341
 protein coding gene Chr5:117793032-117823261 (-)
DBA/2J ENSMUSG00185052196
 protein coding gene Chr5:120844286-120874509 (-)
FVB/NJ ENSMUSG00205039613
 protein coding gene Chr5:116704940-116749315 (-)
JF1/MsJ ENSUMUG00000014855
 protein coding gene Chr5:123708313-123737375 (-)
LP/J ENSMUSG00230043984
 protein coding gene Chr5:124910015-124948612 (-)
NOD/ShiLtJ ENSMUSG00190036046
 protein coding gene Chr5:116718685-116748910 (-)
NZO/HlLtJ ENSMUSG00225013081
 protein coding gene Chr5:132607968-132652343 (-)
PWK/PhJ ENSLUMG00010037589
 protein coding gene Chr5:115600703-115631897 (-)
SPRET/EiJ ENSMSPG00010041983
 protein coding gene Chr5:118908722-118941212 (-)
WSB/EiJ ENSIUOG00005014333
 protein coding gene Chr5:119408445-119453850 (-)



Homology
more
  • Human Ortholog
    VPS33A, VPS33A core subunit of CORVET and HOPS complexes
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VPS33A, VPS33A core subunit of CORVET and HOPS complexes
  • Synonyms
    MPSPS
  • Links
    NCBI Gene ID: 65082
    UniProt: Q96AX1

  • Chr Location
    12q24.31; chr12:122229564-122266502 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Vps33a mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 2 alleles in 3 genetic backgrounds
    2 images
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene produce hypopigmentation, an extended bleeeding time and abnormal kidney function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    50
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    690
  • Tissues
    9
  • cDNA Data
    81
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 77573 NCBI Gene Model | MGI Sequence Detail 44285 C57BL/6J ±  kb
    transcript NM_029929 RefSeq | MGI Sequence Detail 4114 ZRU/MplStud  
    polypeptide Q9D2N9 UniProt | EBI | MGI Sequence Detail 598 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 81
      cDNA 81

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-1541, MGI:2140920, MGI:2141131, MGI:2141231, MGI:88148
    References
    more
    • Summaries
      All 75
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 14
      Phenotypes 30
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory