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Anks1b Gene Detail
Summary
  • Symbol
    Anks1b
  • Name
    ankyrin repeat and sterile alpha motif domain containing 1B
  • Synonyms
    AIDA-1b, C030032C09Rik, E530015N03Rik, Gm10937, LOC380650
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924781
    NCBI Gene: 77531
  • Alliance
    genome feature page
  • Transcription Start Sites
    40 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:89709371-90809162 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 45.28 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    32073 from dbSNP Build 142
  • Strain Annotations
    38
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924781
 protein coding gene Chr10:89707238-90809162 (+)
129S1/SvImJ ENSMUSGG00200054900
 protein coding gene Chr10:86910865-86921411 (+)
129S1/SvImJ ENSMUSGG00200054686
 protein coding gene Chr10:87231305-87305505 (+)
129S1/SvImJ ENSMUSG00200028828
 protein coding gene Chr10:86207383-86844645 (+)
A/J ENSMUSGG00195055216
 protein coding gene Chr10:87346705-87357327 (+)
A/J ENSMUSG00195018293
 protein coding gene Chr10:86655830-87280740 (+)
A/J ENSMUSGG00195055355
 protein coding gene Chr10:87664747-87745316 (+)
AKR/J ENSMUSGG00220054655
 protein coding gene Chr10:86905287-86915918 (+)
AKR/J ENSMUSGG00220054767
 protein coding gene Chr10:87223348-87303914 (+)
AKR/J ENSMUSG00220021282
 protein coding gene Chr10:86214454-86839319 (+)
BALB/cJ ENSMUSGG00180055332
 protein coding gene Chr10:87349565-87360203 (+)
BALB/cJ ENSMUSGG00180055558
 protein coding gene Chr10:87667628-87748180 (+)
BALB/cJ ENSMUSG00180030566
 protein coding gene Chr10:86658770-87283603 (+)
C3H/HeJ ENSMUSG00175021817
 protein coding gene Chr10:86542897-87178491 (+)
C3H/HeJ ENSMUSGG00175054849
 protein coding gene Chr10:87244437-87254982 (+)
C3H/HeJ ENSMUSGG00175054999
 protein coding gene Chr10:87570098-87644195 (+)
C57BL/6NJ ENSMUSGG00215055505
 protein coding gene Chr10:87244521-87318738 (+)
C57BL/6NJ ENSMUSGG00215055507
 protein coding gene Chr10:86924098-86934645 (+)
C57BL/6NJ ENSMUSG00215019952
 protein coding gene Chr10:86210177-86857880 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015722
 protein coding gene Chr10:83674226-84726424 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210031422
 protein coding gene Chr10:86383344-87018939 (+)
CBA/J ENSMUSGG00210054795
 protein coding gene Chr10:87084890-87095435 (+)
CBA/J ENSMUSGG00210054835
 protein coding gene Chr10:87410102-87484233 (+)
DBA/2J ENSMUSG00185039703
 protein coding gene Chr10:86599334-87249423 (+)
DBA/2J ENSMUSGG00185057674
 protein coding gene Chr10:87315449-87326075 (+)
DBA/2J ENSMUSGG00185057881
 protein coding gene Chr10:87633186-87707303 (+)
FVB/NJ ENSMUSG00205012865
 protein coding gene Chr10:86260780-86909496 (+)
FVB/NJ ENSMUSGG00205054486
 protein coding gene Chr10:86975465-86986095 (+)
FVB/NJ ENSMUSGG00205054581
 protein coding gene Chr10:87293514-87374071 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055350
 protein coding gene Chr10:89191156-89201701 (+)
LP/J ENSMUSGG00230055608
 protein coding gene Chr10:89516403-89590498 (+)
LP/J ENSMUSG00230014762
 protein coding gene Chr10:88489654-89125218 (+)
NOD/ShiLtJ ENSMUSG00190016053
 protein coding gene Chr10:86640860-87265628 (+)
NOD/ShiLtJ ENSMUSGG00190054729
 protein coding gene Chr10:87649586-87730133 (+)
NOD/ShiLtJ ENSMUSGG00190054733
 protein coding gene Chr10:87331586-87342212 (+)
NZO/HlLtJ ENSMUSG00225020347
 protein coding gene Chr10:92764237-93389015 (+)
NZO/HlLtJ ENSMUSGG00225055190
 protein coding gene Chr10:93772970-93853516 (+)
NZO/HlLtJ ENSMUSGG00225055188
 protein coding gene Chr10:93454970-93465596 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ANKS1B, ankyrin repeat and sterile alpha motif domain containing 1B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ANKS1B, ankyrin repeat and sterile alpha motif domain containing 1B
  • Synonyms
    ANKS2, cajalin-2, EB-1, EB1
  • Links
    NCBI Gene ID: 56899
    UniProt: Q7Z6G8

  • Chr Location
    12q23.1; chr12:98726457-99984936 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele activated in neurons alters hippocampal synaptic transmission.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    672
  • Tissues
    27
  • cDNA Data
    14
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000058589 Ensembl Gene Model | MGI Sequence Detail 1099792 C57BL/6J ±  kb
transcript ENSMUST00000183156 Ensembl | MGI Sequence Detail 4248 Not Applicable  
polypeptide ENSMUSP00000138539 Ensembl | MGI Sequence Detail 1259 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    27 Sequences
  • Protein Ontology
    PR:000004052 ankyrin repeat and sterile alpha motif domain-containing protein 1B
    (term hierarchy)
  • PDB
    8YM2
  • InterPro Domains
    IPR002110 Ankyrin repeat
    IPR033635 Ankyrin repeat and SAM domain-containing protein 1/Caskin
    IPR041880 Ankyrin repeat and SAM domain-containing protein 1, SAM repeat 1
    IPR041882 Ankyrin repeat and SAM domain-containing protein 1, SAM repeat 2
    IPR036770 Ankyrin repeat-containing domain superfamily
    IPR011993 PH-like domain superfamily
    IPR006020 PTB/PI domain
    IPR001660 Sterile alpha motif domain
    IPR013761 Sterile alpha motif/pointed domain superfamily
  • GlyGen
    Q8BIZ1 6 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (4 sites)
Molecular
Reagents
less
  • All nucleic 17
    cDNA 16
    Primer pair 1
    Antibodies 4

    Microarray probesets 11
Other
Accession IDs
less
MGI:2686401, MGI:3779147
References
more
  • Summaries
    All 49
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 18
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:379647 Ou F, et al., Complete stranded RNA profiling during early mouse gonad development. NAR Mol Med. 2025 Apr;2(2):ugaf014
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory