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Nkrf Gene Detail
Summary
  • Symbol
    Nkrf
  • Name
    NF-kappaB repressing factor
  • Synonyms
    9430034D17Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924536
    NCBI Gene: 77286
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:36151193-36167166 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 21.30 cM, cytoband A2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    251 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924536
 protein coding gene ChrX:36149644-36167166 (-)
129S1/SvImJ ENSMUSG00200021830
 protein coding gene ChrX:20260629-20276602 (-)
A/J ENSMUSG00195024825
 protein coding gene ChrX:22931188-22947164 (-)
AKR/J ENSMUSG00220023915
 protein coding gene ChrX:20042650-20058626 (-)
BALB/cJ ENSMUSG00180012125
 protein coding gene ChrX:20489556-20505530 (-)
C3H/HeJ ENSMUSG00175022749
 protein coding gene ChrX:23631689-23647662 (-)
C57BL/6NJ ENSMUSG00215015615
 protein coding gene ChrX:20682893-20698868 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032995
 protein coding gene ChrX:30108458-30123560 (-)
CAST/EiJ ENSTCUG00005030773
 protein coding gene ChrX:22576176-22592140 (-)
CBA/J ENSMUSG00210034509
 protein coding gene ChrX:20927575-20943549 (-)
DBA/2J ENSMUSG00185024312
 protein coding gene ChrX:31508484-31524458 (-)
FVB/NJ ENSMUSG00205019381
 protein coding gene ChrX:19603406-19619382 (-)
JF1/MsJ ENSUMUG00000028902
 protein coding gene ChrX:50620559-50636494 (-)
LP/J ENSMUSG00230011143
 protein coding gene ChrX:38000719-38016694 (-)
NOD/ShiLtJ ENSMUSG00190020652
 protein coding gene ChrX:20201730-20217704 (-)
NZO/HlLtJ ENSMUSG00225039050
 protein coding gene ChrX:43207139-43223112 (-)
PWK/PhJ ENSLUMG00010034339
 protein coding gene ChrX:20330611-20346561 (-)
SPRET/EiJ ENSMSPG00010017175
 protein coding gene ChrX:21562552-21578459 (-)
WSB/EiJ ENSIUOG00005037682
 protein coding gene ChrX:21117580-21133544 (-)



Homology
more
  • Human Ortholog
    NKRF, NFKB repressing factor
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NKRF, NFKB repressing factor
  • Synonyms
    ITBA4, NRF, XTBD3
  • Links
    NCBI Gene ID: 55922
    UniProt: O15226

  • Chr Location
    Xq24; chrX:119588337-119606443 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotype references
Homozygous female and hemizygous male null mice are viable and fertile with normal inflammatory responses, response to infection, peripheral blood cell populations and skin morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    716
  • Tissues
    110
  • cDNA Data
    36
  • Literature Summary
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000044149 Ensembl Gene Model | MGI Sequence Detail 15974 C57BL/6J ±  kb
transcript ENSMUST00000239259 Ensembl | MGI Sequence Detail 3882 Not Applicable  
polypeptide ENSMUSP00000159216 Ensembl | MGI Sequence Detail 784 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 38
    Genomic 2
    cDNA 36

    Microarray probesets 6
Other
Accession IDs
less
MGI:2148002, MGI:2148062
References
more
  • Summaries
    All 42
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 9
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:343191 Guo C, et al., NKRF in Cardiac Fibroblasts Protects against Cardiac Remodeling Post-Myocardial Infarction via Human Antigen R. Adv Sci (Weinh). 2023 Oct;10(30):e2303283
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory