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Ctrc Gene Detail
Summary
  • Symbol
    Ctrc
  • Name
    chymotrypsin C
  • Synonyms
    1810044E12Rik, caldecrin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923951
    NCBI Gene: 76701
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:141565550-141573598 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 74.75 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    374 from dbSNP Build 142
  • Strain Annotations
    14
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923951
 protein coding gene Chr4:141565550-141573670 (-)
129S1/SvImJ ENSMUSG00200042623
 protein coding gene Chr4:134988593-134996789 (-)
A/J ENSMUSG00195031348
 protein coding gene Chr4:136335506-136343623 (-)
AKR/J ENSMUSG00220040790
 protein coding gene Chr4:135334995-135343022 (-)
BALB/cJ ENSMUSG00180040002
 protein coding gene Chr4:133975158-133983185 (-)
C3H/HeJ ENSMUSG00175035105
 protein coding gene Chr4:135001731-135009762 (-)
C57BL/6NJ ENSMUSG00215048243
 protein coding gene Chr4:136518094-136526212 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026755
 protein coding gene Chr4:131531624-131539066 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210027242
 protein coding gene Chr4:134625647-134633676 (-)
DBA/2J ENSMUSG00185050940
 protein coding gene Chr4:136129089-136137728 (-)
FVB/NJ ENSMUSG00205027430
 protein coding gene Chr4:134385272-134393386 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230038928
 protein coding gene Chr4:139926590-139935224 (-)
NOD/ShiLtJ ENSMUSG00190031468
 protein coding gene Chr4:134380453-134389094 (-)
NZO/HlLtJ ENSMUSG00225009621
 protein coding gene Chr4:145873918-145882031 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CTRC, chymotrypsin C
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CTRC, chymotrypsin C
  • Synonyms
    CLCR, ELA4
  • Links
    NCBI Gene ID: 11330
    UniProt: Q99895

  • Chr Location
    1p36.21; chr1:15438442-15449242 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CTRC associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous single base deletion are more susceptible to secretagogue-induced pancreatitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    8
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    89
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    • All Sequences
      31
    • RefSeq
      3
    • UniProt
      1
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 76701 NCBI Gene Model | MGI Sequence Detail 8049 C57BL/6J ±  kb
    transcript NM_001033875 RefSeq | MGI Sequence Detail 972 Not Specified  
    polypeptide Q3SYP2 UniProt | EBI | MGI Sequence Detail 268 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 89
      cDNA 89

      Microarray probesets 2
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 10
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory