Ppp1r18 MGI Mouse Gene Detail - MGI:1923698 - protein phosphatase 1, regulatory subunit 18

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Ppp1r18 Gene Detail

Symbol

Ppp1r18
Name

protein phosphatase 1, regulatory subunit 18
Synonyms

2310014H01Rik

Feature Type

protein coding gene
IDs

MGI:1923698
NCBI Gene: 76448
Alliance

genome feature page
Transcription Start Sites

31 TSS

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Sequence Map

Chr17:36176485-36186488 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 17, 18.72 cM
Mapping Data

2 experiments

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Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_1923698	protein coding gene	Chr17:36176483-36186488 (+)
129S1/SvImJ	ENSMUSG00200047013	protein coding gene	Chr17:31801638-31811604 (+)
A/J	ENSMUSG00195042994	protein coding gene	Chr17:32863756-32873742 (+)
AKR/J	ENSMUSG00220049674	protein coding gene	Chr17:31665007-31674973 (+)
BALB/cJ	ENSMUSG00180033268	protein coding gene	Chr17:32233548-32243534 (+)
C3H/HeJ	ENSMUSG00175026553	protein coding gene	Chr17:31550848-31560815 (+)
C57BL/6NJ	ENSMUSG00215046606	protein coding gene	Chr17:31627049-31637055 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021537	protein coding gene	Chr17:32642513-32652142 (+)
CAST/EiJ	ENSTCUG00005039450	protein coding gene	Chr17:32693262-32703062 (+)
CBA/J	ENSMUSG00210037927	protein coding gene	Chr17:31372906-31382874 (+)
DBA/2J	ENSMUSG00185046141	protein coding gene	Chr17:34252699-34262684 (+)
FVB/NJ	ENSMUSG00205037967	protein coding gene	Chr17:31919956-31929764 (+)
JF1/MsJ	ENSUMUG00000033906	protein coding gene	Chr17:33210642-33220426 (+)
LP/J	ENSMUSG00230054556	protein coding gene	Chr17:35290315-35300278 (+)
NOD/ShiLtJ	ENSMUSG00190043002	protein coding gene	Chr17:31539073-31548882 (+)
NZO/HlLtJ	ENSMUSG00225050497	protein coding gene	Chr17:37367027-37377017 (+)
PWK/PhJ	ENSLUMG00010042819	protein coding gene	Chr17:31173681-31183473 (+)
SPRET/EiJ	ENSMSPG00010049554	protein coding gene	Chr17:32389299-32399098 (+)
WSB/EiJ	ENSIUOG00005043760	protein coding gene	Chr17:32356076-32366037 (+)

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Human Ortholog

PPP1R18, protein phosphatase 1 regulatory subunit 18

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PPP1R18, protein phosphatase 1 regulatory subunit 18
Synonyms

HKMT1098, KIAA1949
Links

HGNC:29413

NCBI Gene ID: 170954

UniProt: Q6NYC8
Chr Location

6p21.33; chr6:30676389-30688391 (-) GRCh38

MGI Vertebrate Homology

Ppp1r18 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: PPP1R18
Gene Tree

Ppp1r18

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Phenotype Summary

10 phenotypes from 3 alleles in 3 genetic backgrounds
8 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

31
Endonuclease-mediated

7
Gene trapped

22
Targeted

2
Genomic Mutations

1 involving Ppp1r18
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

36 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit spleen hypoplasia, impaired CD4+ T cell homing, increased white blood cell, lymphocyte, and neutrophil, and reduced B and T cell numbers in the lymph nodes, peripheral lymph nodes, and spleen.

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All GO Annotations

2
GO References

2

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

No experimental evidence to support Biological Process annotation, following literature review. See J:73796.

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

681
Tissues

12
cDNA Data

9
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

64
RefSeq

11
UniProt

5
CCDS

CCDS50094.1

Ensembl

ENSMUSG00000034595 (Evidence)
NCBI Gene

76448

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000034595	Ensembl Gene Model \| MGI Sequence Detail	10004	C57BL/6J	± kb
	transcript	ENSMUST00000127442	Ensembl \| MGI Sequence Detail	3524	Not Applicable
	polypeptide	ENSMUSP00000115753	Ensembl \| MGI Sequence Detail	609	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000032625 phostensin

(term hierarchy)
InterPro Domains

IPR026671 Phostensin/Taperin

IPR025903 Phostensin/Taperin N-terminal domain

IPR025907 Phostensin/Taperin PP1-binding domain
GlyGen

Q8BQ30 2 sites, 1 O-linked glycan (1 site)

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All nucleic 9

cDNA 9

Microarray probesets 3

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MGI:2146745, MGI:2146864

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Summaries

All 34

Developmental Gene Expression 1

Gene Ontology 2

Phenotypes 8
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:331428 Lee HS, et al., Phostensin enables lymphocyte integrin activation and population of peripheral lymphoid organs. J Exp Med. 2022 Aug 1;219(8):e20211637

TSS for Ppp1r18:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr144431	Chr17:36176679-36176735 (+)	222 bp
Tssr144432	Chr17:36176963-36176977 (+)	485 bp
Tssr144433	Chr17:36177013-36177036 (+)	540 bp
Tssr144434	Chr17:36177044-36177095 (+)	585 bp
Tssr144435	Chr17:36177137-36177148 (+)	658 bp
Tssr144436	Chr17:36177498-36177567 (+)	1,048 bp
Tssr144437	Chr17:36177569-36177591 (+)	1,095 bp
Tssr144438	Chr17:36177592-36177611 (+)	1,117 bp
Tssr144439	Chr17:36177713-36177724 (+)	1,234 bp
Tssr144440	Chr17:36177734-36177744 (+)	1,254 bp
Tssr144441	Chr17:36177747-36177769 (+)	1,273 bp
Tssr144442	Chr17:36177824-36177838 (+)	1,346 bp
Tssr144443	Chr17:36177933-36177950 (+)	1,457 bp
Tssr144444	Chr17:36178041-36178058 (+)	1,565 bp
Tssr144445	Chr17:36178071-36178125 (+)	1,613 bp
Tssr144446	Chr17:36178637-36178667 (+)	2,167 bp
Tssr144447	Chr17:36178670-36178681 (+)	2,191 bp
Tssr144448	Chr17:36178895-36178906 (+)	2,416 bp
Tssr144449	Chr17:36179274-36179341 (+)	2,823 bp
Tssr144450	Chr17:36179347-36179351 (+)	2,864 bp
Tssr144451	Chr17:36179353-36179384 (+)	2,884 bp
Tssr144452	Chr17:36179409-36179413 (+)	2,926 bp
Tssr144453	Chr17:36179471-36179482 (+)	2,992 bp
Tssr144454	Chr17:36179510-36179539 (+)	3,040 bp
Tssr144455	Chr17:36179610-36179622 (+)	3,131 bp
Tssr144456	Chr17:36180559-36180608 (+)	4,099 bp
Tssr144457	Chr17:36184718-36184730 (+)	8,239 bp
Tssr144458	Chr17:36184760-36184806 (+)	8,298 bp
Tssr144459	Chr17:36185826-36185833 (+)	9,345 bp
Tssr144460	Chr17:36185865-36185891 (+)	9,393 bp
Tssr144461	Chr17:36185977-36186002 (+)	9,505 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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