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Cep112 Gene Detail
Summary
  • Symbol
    Cep112
  • Name
    centrosomal protein 112
  • Synonyms
    1700001M19Rik, 1700029K01Rik, 8430407H02Rik, Ccdc46, Macoco
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923673
    NCBI Gene: 76380
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:108316041-108751441 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 71.83 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10714 from dbSNP Build 142
  • Strain Annotations
    27
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923673
 protein coding gene Chr11:108316018-108751441 (+)
129S1/SvImJ ENSMUSGG00200054939
 protein coding gene Chr11:105797126-106077701 (+)
129S1/SvImJ ENSMUSG00200032803
 protein coding gene Chr11:105632672-105740944 (+)
A/J ENSMUSG00195020708
 protein coding gene Chr11:105338878-105447152 (+)
A/J ENSMUSGG00195055343
 protein coding gene Chr11:105503336-105781279 (+)
AKR/J ENSMUSG00220028707
 protein coding gene Chr11:105546082-105641024 (+)
AKR/J ENSMUSGG00220054562
 protein coding gene Chr11:105696619-105962974 (+)
BALB/cJ ENSMUSGG00180054976
 protein coding gene Chr11:105819872-106099385 (+)
BALB/cJ ENSMUSG00180015979
 protein coding gene Chr11:105655336-105763671 (+)
C3H/HeJ ENSMUSGG00175054845
 protein coding gene Chr11:105768842-106049202 (+)
C3H/HeJ ENSMUSG00175012844
 protein coding gene Chr11:105604395-105712667 (+)
C57BL/6NJ ENSMUSG00215014742
 protein coding gene Chr11:105165258-105262556 (+)
C57BL/6NJ ENSMUSGG00215055436
 protein coding gene Chr11:105318225-105591776 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017343
 protein coding gene Chr11:104336382-104753775 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210013583
 protein coding gene Chr11:105312162-105420432 (+)
CBA/J ENSMUSGG00210054494
 protein coding gene Chr11:105476617-105754540 (+)
DBA/2J ENSMUSG00185018262
 protein coding gene Chr11:105654124-105762402 (+)
DBA/2J ENSMUSGG00185057525
 protein coding gene Chr11:105818571-106096495 (+)
FVB/NJ ENSMUSGG00205054272
 protein coding gene Chr11:105615675-105917486 (+)
FVB/NJ ENSMUSG00205024102
 protein coding gene Chr11:105451229-105559494 (+)
JF1/MsJ no annotation
LP/J ENSMUSGG00230055547
 protein coding gene Chr11:106870490-107148411 (+)
LP/J ENSMUSG00230029371
 protein coding gene Chr11:106706045-106814311 (+)
NOD/ShiLtJ ENSMUSG00190020293
 protein coding gene Chr11:105658129-105766409 (+)
NOD/ShiLtJ ENSMUSGG00190054766
 protein coding gene Chr11:105822586-106100496 (+)
NZO/HlLtJ ENSMUSG00225050955
 protein coding gene Chr11:108742106-108850447 (+)
NZO/HlLtJ ENSMUSGG00225055623
 protein coding gene Chr11:108906648-109196520 (+)
PWK/PhJ no annotation
SPRET/EiJ ENSMSPG00010032011
 protein coding gene Chr11:105920199-106361753 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    CEP112, centrosomal protein 112
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CEP112, centrosomal protein 112
  • Synonyms
    CCDC46, MACOCO, SPGF44
  • Links
    NCBI Gene ID: 201134
    UniProt: Q8N8E3

  • Chr Location
    17q24.1; chr17:65635537-66192251 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CEP112 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    27
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 76380 NCBI Gene Model | MGI Sequence Detail 435401 C57BL/6J ±  kb
    transcript NM_029606 RefSeq | MGI Sequence Detail 3516 C57BL/6  
    polypeptide Q5PR68 UniProt | EBI | MGI Sequence Detail 954 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 27

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1918712, MGI:1923630, MGI:2142738, MGI:2144454
    References
    more
    • Summaries
      All 33
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 4
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:357758 Zhang X, et al., CEP112 coordinates translational regulation of essential fertility genes during spermiogenesis through phase separation in humans and mice. Nat Commun. 2024 Sep 30;15(1):8465
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory