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Zdhhc5 Gene Detail
Summary
  • Symbol
    Zdhhc5
  • Name
    zinc finger, DHHC domain containing 5
  • Synonyms
    1110032A17Rik, Zisp
  • Feature Type
    protein coding gene
  • IDs
    MGI:1923573
    NCBI Gene: 228136
  • Alliance
    genome feature page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:84518314-84545524 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 49.45 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    500 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1923573
 protein coding gene Chr2:84518264-84545524 (-)
129S1/SvImJ ENSMUSG00200053039
 protein coding gene Chr2:81534735-81561942 (-)
A/J ENSMUSG00195048529
 protein coding gene Chr2:81647641-81675023 (-)
AKR/J ENSMUSG00220049860
 protein coding gene Chr2:81526319-81553702 (-)
BALB/cJ ENSMUSG00180054593
 protein coding gene Chr2:81575479-81602863 (-)
C3H/HeJ ENSMUSG00175051917
 protein coding gene Chr2:81715074-81742463 (-)
C57BL/6NJ ENSMUSG00215052149
 protein coding gene Chr2:81619830-81647039 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023725
 protein coding gene Chr2:78898091-78927135 (-)
CAST/EiJ ENSTCUG00005052080
 protein coding gene Chr2:81065790-81092884 (-)
CBA/J ENSMUSG00210031773
 protein coding gene Chr2:81742976-81770361 (-)
DBA/2J ENSMUSG00185057073
 protein coding gene Chr2:81571722-81599107 (-)
FVB/NJ ENSMUSG00205048021
 protein coding gene Chr2:80953311-80980497 (-)
JF1/MsJ ENSUMUG00000004240
 protein coding gene Chr2:81497386-81525028 (-)
LP/J ENSMUSG00230039633
 protein coding gene Chr2:83322825-83350209 (-)
NOD/ShiLtJ ENSMUSG00190039542
 protein coding gene Chr2:81612271-81639434 (-)
NZO/HlLtJ ENSMUSG00225001928
 protein coding gene Chr2:91207386-91234574 (-)
PWK/PhJ ENSLUMG00010043840
 protein coding gene Chr2:81512773-81540311 (-)
SPRET/EiJ ENSMSPG00010052013
 protein coding gene Chr2:83410374-83433540 (-)
WSB/EiJ ENSIUOG00005052835
 protein coding gene Chr2:81551795-81579185 (-)



Homology
more
  • Human Ortholog
    ZDHHC5, zDHHC palmitoyltransferase 5
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZDHHC5, zDHHC palmitoyltransferase 5
  • Synonyms
    DHHC5, ZNF375
  • Links
    NCBI Gene ID: 25921
    UniProt: Q9C0B5

  • Chr Location
    11q12.1; chr11:57667433-57701190 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 4 alleles in 4 genetic backgrounds
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic allele exhibit partial prenatal lethality and impaired contextual conditioning. Mice homozygous for a conditional allele activated in adipocytes exhibit impaired fatty acid uptake and impairedadaptive thermogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    74
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    609
  • Tissues
    12
  • cDNA Data
    14
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034075 Ensembl Gene Model | MGI Sequence Detail 27211 C57BL/6J ±  kb
    transcript ENSMUST00000035840 Ensembl | MGI Sequence Detail 4706 Not Applicable  
    polypeptide ENSMUSP00000048198 Ensembl | MGI Sequence Detail 715 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 14
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2138961
    References
    more
    • Summaries
      All 78
      Developmental Gene Expression 2
      Gene Ontology 20
      Phenotypes 30
    • Earliest
      J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
    • Latest
      J:387460 Zhang Q, et al., Druggable beta-catenin palmitoyl-switch coordinates immune evasion via immunogenic ferroptosis resistance and PD-L1-mediated immunosuppression. Cell Rep Med. 2026 May 28;:102837
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory